2. GPCR/G Protein Neuronal Signaling
  3. Cannabinoid Receptor
  4. SMM-189

SMM-189 is  a potent and selective cannabinoid receptor 2 (CB2) inverse agonist. SMM-189 plays an important role in neurodegenerative disorders and traumatic brain injury research.

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SMM-189 Chemical Structure

SMM-189 Chemical Structure

CAS No. : 1054451-07-8

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SMM-189 Related Antibodies

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Description

SMM-189 is  a potent and selective cannabinoid receptor 2 (CB2) inverse agonist. SMM-189 plays an important role in neurodegenerative disorders and traumatic brain injury research[1].

IC50 & Target

CB2

 

Cellular Effect
Cell Line Type Value Description References
HEK293 EC50
153 nM
Compound: SMM-189
Inverse agonist activity at CB2 receptor (unknown origin) expressed in HEK cells assessed as increase in cAMP production measured at 50 mins by ACTOne dye-based fluorescence assay in presence of forskolin and Ro 20-1724
Inverse agonist activity at CB2 receptor (unknown origin) expressed in HEK cells assessed as increase in cAMP production measured at 50 mins by ACTOne dye-based fluorescence assay in presence of forskolin and Ro 20-1724
[PMID: 26275680]
Molecular Weight

359.20

Formula

C19H12Cl2O3
CAS No.
SMILES

O=C(C1=CC(O)=C(C2=CC(Cl)=CC(Cl)=C2)C(O)=C1)C3=CC=CC=C3
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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SMM-189 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SMM-1891054451-07-8SMM189SMM 189Cannabinoid ReceptorInhibitorinhibitorinhibit

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