SMO-IN-1

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SMO-IN-1 (Compound 15) is an orally active Smoothened (SMO) inhibitor with an EC₅₀ of 89 nM against sonic Hh protein (shh).

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SMO-IN-1 Chemical Structure

CAS No. : 1126365-66-9

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Description

SMO-IN-1 (Compound 15) is an orally active Smoothened (SMO) inhibitor with an EC₅₀ of 89 nM against sonic Hh protein (shh)^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
C3H 10T1/2	EC₅₀	0.089 μM Compound: 11g	Inhibition of Smo expressed in mouse C3H10T1/2 cells assessed as reduction in alkaline phosphatase level after 72 hrs by spectrophotometric analysis Inhibition of Smo expressed in mouse C3H10T1/2 cells assessed as reduction in alkaline phosphatase level after 72 hrs by spectrophotometric analysis	[PMID: 22704236]
C3H 10T1/2	EC₅₀	89 nM Compound: 15	Inhibition of SMO-mediated Hedgehog signaling pathway in mouse C3H10T1/2 cells assessed as reduction in sonic hedgehog-induced osteoblast differentiation by measuring alkaline phosphatase activity incubated for 72 hrs Inhibition of SMO-mediated Hedgehog signaling pathway in mouse C3H10T1/2 cells assessed as reduction in sonic hedgehog-induced osteoblast differentiation by measuring alkaline phosphatase activity incubated for 72 hrs	[PMID: 31862310]
NIH3T3	IC₅₀	0.005 μM Compound: 11g	Inhibition of Smo expressed in mouse NIH/3T3 cells after 20 hrs by Gli reporter gene assay Inhibition of Smo expressed in mouse NIH/3T3 cells after 20 hrs by Gli reporter gene assay	[PMID: 22704236]

Molecular Weight

398.46

Formula

C₂₄H₂₂N₄O₂

CAS No.

1126365-66-9

SMILES

CC1=CC=C(C=C1NC(C2=CC=C(C=C2)OCC3=NC=CC=C3)=O)C4=CN(C=N4)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Yang B, et al. Heteroarylamide smoothened inhibitors: Discovery of N-[2,4-dimethyl-5-(1-methylimidazol-4-yl)phenyl]-4-(2-pyridylmethoxy)benzamide (AZD8542) and N-[5-(1H-imidazol-2-yl)-2,4-dimethyl-phenyl]-4-(2- pyridylmethoxy)benzamide (AZD7254). Bioorg M [Content Brief]

SMO-IN-1 Related Classifications

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SMO-IN-11126365-66-9SmoSmoothenedmetastasized basal cell carcinomaantitumorsonic Hh proteinshhInhibitorinhibitorinhibit

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