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  4. SMS2-IN-3

SMS2-IN-3 is a potent and selective SMS2inhibitor (IC50=2.2 nM), significantly reduces the hepatic SM (22:0) levels.

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SMS2-IN-3 Chemical Structure

SMS2-IN-3 Chemical Structure

CAS No. : 2414240-89-2

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SMS2-IN-3 Related Antibodies

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Description

SMS2-IN-3 is a potent and selective SMS2inhibitor (IC50=2.2 nM), significantly reduces the hepatic SM (22:0) levels[1].

IC50 & Target

IC50: 2.2nM (SMS2)[1]
In Vitro

SMS2-IN-3 (37) is an excellent sphingomyelin synthase 2 inhibitor (SMS2). SMS2-IN-3 (37) has inhibition (IC50= 2.2 nM) and good selectivity against SMS1[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SMS2-IN-3 Related Antibodies

Cell Viability Assay[1]

Cell Line: FreeStyle293 cells
Concentration: 100mg/kg
Incubation Time: 60 min
Result: Showed excellent SMS2 inhibition and good selectivity against SMS1 in biological evaluation.
In Vivo

SMS2-IN-3 (37) has excellent SMS2 activity and high selectivity against SMS1. SMS2-IN-3 also reduces the level of SM by subcutaneous treatment[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: KK-Ay/Ta mice[1]
Dosage: 100, 200 mg/kg
Administration: SMS2-IN-3: s.c. (100, 200 mg/kg); p.o. (100, 200 mg/kg); once or twice per day for 7 days.
Result:
cmpd Cmax, (μg/mL) Tmax, (h) C24 h, (μg/mL) AUC0-24(μg•h/mL) MRT(h)
37(p.o.) 6.5 0.83 0.007 18 3.0
37(s.c.) 0.70 8.0 0.23 12 9.4
Molecular Weight

644.68

Formula

C33H39F3N4O6
CAS No.
SMILES

O=C(N1CCC(CCCOC(C2=C(N3C)N=CC=C2)=C(C(N(CC4=CC(OC)=CC(C(F)(F)F)=C4)C)=O)C3=O)CC1)OC5(CC5)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SMS2-IN-3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SMS2-IN-32414240-89-2Otherssphingomyelin synthase 2SMS2Inhibitorinhibitorinhibit

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