Spermine NONOate

Name: Spermine NONOate
Brand: MedChemExpress
SKU: HY-101394
Rating: 4.5 (1 reviews)

Cat. No.: HY-101394 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Spermine NONOate is a complex of nitric oxide (NO) with spermine and acts as a NO donor. Spermine NONOate can be used for NO aqueous solutions preparing.

For research use only. We do not sell to patients.

Spermine NONOate Chemical Structure

CAS No. : 136587-13-8

Size	Price	Stock	Quantity
5 mg	USD 68	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 110	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 220	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

Spermine NONOate is a complex of nitric oxide (NO) with spermine and acts as a NO donor. Spermine NONOate can be used for NO aqueous solutions preparing^[1].

In Vitro

Spermine NONOate has a half-life of 39 minutes and 230 minutes at 37°C and 22-25°C, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

262.35

Formula

C₁₀H₂₆N₆O₂

CAS No.

136587-13-8

Appearance

Solid

Color

White to off-white

SMILES

NCCCNCCCCN(CCCN)N(O)N=O

Shipping

Shipping with dry ice.

Storage

-80°C, protect from light, stored under nitrogen

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (381.17 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.8117 mL	19.0585 mL	38.1170 mL
5 mM	0.7623 mL	3.8117 mL	7.6234 mL
10 mM	0.3812 mL	1.9059 mL	3.8117 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 50 mg/mL (190.59 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (266 KB) SDS (252 KB)

COA (241 KB) HNMR (262 KB)

Handling Instructions (2659 KB)

References

[1]. A Ramamurthi , et al. Measurement and modeling of nitric oxide release rates for nitric oxide donors. Chem Res Toxicol. 1997 Apr;10(4):408-13. [Content Brief]

[2]. K Homer, et al. In vitro comparison of two NONOates (novel nitric oxide donors) on rat pulmonary arteries. Eur J Pharmacol. 1998 Aug 28;356(1):49-57. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	3.8117 mL	19.0585 mL	38.1170 mL	95.2925 mL
	5 mM	0.7623 mL	3.8117 mL	7.6234 mL	19.0585 mL
	10 mM	0.3812 mL	1.9059 mL	3.8117 mL	9.5293 mL
	15 mM	0.2541 mL	1.2706 mL	2.5411 mL	6.3528 mL
	20 mM	0.1906 mL	0.9529 mL	1.9059 mL	4.7646 mL
	25 mM	0.1525 mL	0.7623 mL	1.5247 mL	3.8117 mL
	30 mM	0.1271 mL	0.6353 mL	1.2706 mL	3.1764 mL
	40 mM	0.0953 mL	0.4765 mL	0.9529 mL	2.3823 mL
	50 mM	0.0762 mL	0.3812 mL	0.7623 mL	1.9059 mL
	60 mM	0.0635 mL	0.3176 mL	0.6353 mL	1.5882 mL
	80 mM	0.0476 mL	0.2382 mL	0.4765 mL	1.1912 mL
	100 mM	0.0381 mL	0.1906 mL	0.3812 mL	0.9529 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.