2. GPCR/G Protein
  3. Leukotriene Receptor
  4. SR2640

SR2640 is a highly efficient and selective LTD4/LTE4 antagonist that can specifically inhibit the smooth muscle contractions induced by LTD4 in the guinea pig ileum and trachea in a concentration-dependent manner, without affecting the contractions caused by histamine. SR2640 can concentration-dependently prevent the binding of 0.4 nM [3H] LTD4 to membrane receptors in guinea pig lung tissue, with an IC50 of 23 nM. SR2640 can shift the dose-response curve for bronchoconstriction induced by intravenous LTD4 in guinea pigs to the right, and the extent of this shift is positively correlated with the dose of SR2640 administered. SR2640 can be used in asthma research.

For research use only. We do not sell to patients.

SR2640 Chemical Structure

SR2640 Chemical Structure

CAS No. : 105350-26-3

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SR2640 Related Antibodies

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Description

SR2640 is a highly efficient and selective LTD4/LTE4 antagonist that can specifically inhibit the smooth muscle contractions induced by LTD4 in the guinea pig ileum and trachea in a concentration-dependent manner, without affecting the contractions caused by histamine. SR2640 can concentration-dependently prevent the binding of 0.4 nM [3H] LTD4 to membrane receptors in guinea pig lung tissue, with an IC50 of 23 nM. SR2640 can shift the dose-response curve for bronchoconstriction induced by intravenous LTD4 in guinea pigs to the right, and the extent of this shift is positively correlated with the dose of SR2640 administered. SR2640 can be used in asthma research[1].

Molecular Weight

370.40

Formula

C23H18N2O3
CAS No.
SMILES

O=C(O)C1=CC=CC=C1NC2=CC=CC(OCC3=NC4=CC=CC=C4C=C3)=C2
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
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SR2640 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SR2640105350-26-3QMPBSR 2640SR-2640Leukotriene ReceptorIntravenous injectionguinea pig lung tissueguinea pig ileumtracheaInhibitorinhibitorinhibit

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