SSR182289  (Synonyms: SSR182289A free base)

SSR182289 (SSR182289A free base) is a selective and potent orally active thrombin inhibitor. SSR182289 competitively and selectivity inhibits human thrombin (K_i=0.031 μM). SSR182289 demonstrates anticoagulant activity in vitro (thrombin time EC₁₀₀=96 nM) and inhibits tissue factor-induced thrombin generation (IC₅₀=0.15 μM) in human plasma. SSR182289 inhibits thrombin-induced aggregation of human platelets (IC₅₀=32 nM), but has no effect on aggregation induced by other platelet agonists ^[1][2].

597.68

C₃₀H₃₃F₂N₅O₄S

363151-21-7

CC(NC1=C(S(=O)(N[C@H](C(N2CC/C(CC2)=C(F)/F)=O)CCCC3=NC=C(N)C=C3)=O)C=CC=C1C4=CC=CC=C4)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Jean-Michel Altenburger, et al. SSR182289A, a selective and potent orally active thrombin inhibitor. Bioorg Med Chem. 2004 Apr 1;12(7):1713-30.  [Content Brief]

  [2]. Jean-Michel Altenburger, et al. SSR182289A, a selective and potent orally active thrombin inhibitor. Bioorg Med Chem. 2004 Apr 1;12(7):1713-30.  [Content Brief]