1. Anti-infection
  2. Antibiotic Bacterial
  3. Sulfamethoxazole 1000 µg/mL in methanol

Sulfamethoxazole 1000 µg/mL in methanol  (Synonyms: Ro 4-2130 1000 µg/mL in methanol)

Cat. No.: HY-B0322B Purity: ≥90.0%
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Sulfamethoxazole (Ro 4-2130) 1000 μg/mL in methanol is a sulfonamide antibiotic with a widespread antibacterial activity. Sulfamethoxazole 1000 μg/mL in methanol inhibits bacterial folate metabolism by competing with 4-Aminobenzoic acid (HY-B1008) (PABA) to act on dihydropteroate synthetase and dihydropteroate reductase. Sulfamethoxazole 1000 μg/mL in methanol can be used for the study of urinary tract infections (UTIs), prostatitis, and bronchitis.

For research use only. We do not sell to patients.

Sulfamethoxazole 1000 µg/mL in methanol Chemical Structure

Sulfamethoxazole 1000 µg/mL in methanol Chemical Structure

CAS No. : 723-46-6

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Description

Sulfamethoxazole (Ro 4-2130) 1000 μg/mL in methanol is a sulfonamide antibiotic with a widespread antibacterial activity. Sulfamethoxazole 1000 μg/mL in methanol inhibits bacterial folate metabolism by competing with 4-Aminobenzoic acid (HY-B1008) (PABA) to act on dihydropteroate synthetase and dihydropteroate reductase. Sulfamethoxazole 1000 μg/mL in methanol can be used for the study of urinary tract infections (UTIs), prostatitis, and bronchitis[1][2][3].

In Vitro

Sulfamethoxazole (0.01-1.28 mg/mL; 120 h) inhibits P. lutzii mitochondrial activity[1].
Sulfamethoxazole (0.01 mg/mL; 1-2 h) acts in P. lutzii as a competitor for amino acid, nucleic acids and folate cofactor biosynthesis, disrupting mitochondrial functions[1].
Sulfamethoxazole at different concentrations, by using the whole-cell patch clamp recording method, inhibits the KATP channel currents in mouse pancreatic β cells in a dose-dependent manner, and the IC50 is 0.46 mM[3].
Sulfamethoxazole at different concentrations, through the static incubation assay of islets, stimulates insulin secretion in mouse islets. It can stimulate insulin secretion at a low concentration (0.1 mM) under high-glucose (10 mM) conditions and only at a high concentration (10 mM) under low-glucose (2 mM) conditions[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: P. lutzii yeast cells
Concentration: 1.28 mg/mL, 0.64 mg/mL, 0.32 mg/mL, 0.16 mg/mL, 0.08 mg/mL, 0.04 mg/mL, 0.02 mg/mL, and 0.01 mg/mL
Incubation Time: 120 h
Result: Produced a marked dose-dependent adverse effect on P. lutzii.

RT-PCR[1]

Cell Line: P. lutzii yeast cells
Concentration: 0.01 mg/mL
Incubation Time: 1 or 2 h
Result: The up-regulated genes included those for HSP70, HSP60, and HSP30.
The down-regulated genes included betaine aldehyde dehydrogenase (BADH), carnitine/acyl carnitine carrier (ACUH), guanine nucleotide binding protein α-1 subunit (GPA2), C6 transcription factor (CTF1B) and pleckstrin homology domain (PH).
Molecular Weight

253.28

Formula

C10H11N3O3S

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(NC1=NOC(C)=C1)(C2=CC=C(C=C2)N)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥90.0%

References
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Sulfamethoxazole 1000 µg/mL in methanol Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Sulfamethoxazole 1000 µg/mL in methanol
Cat. No.:
HY-B0322B
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