2. Immunology/Inflammation Neuronal Signaling
  3. PD-1/PD-L1 Monoamine Oxidase
  4. SWS1

SWS1 is a d-(+)-biotin-conjugated PD-L1 inhibitor (IC50: 1.8 nM) with anticancer activity. SWS1 can increase the number of tumor-infiltrating lymphocytes and exhibit anti-tumor efficacy in the B16-F10 mouse model (TGI=66.1%).

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SWS1 Chemical Structure

SWS1 Chemical Structure

CAS No. : 2922115-32-8

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SWS1 Related Antibodies

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Description

SWS1 is a d-(+)-biotin-conjugated PD-L1 inhibitor (IC50: 1.8 nM) with anticancer activity. SWS1 can increase the number of tumor-infiltrating lymphocytes and exhibit anti-tumor efficacy in the B16-F10 mouse model (TGI=66.1%)[1].

IC50 & Target

IC50: 1.8 nM (PD-1/PD-L1)[1]
Molecular Weight

849.48

Formula

C47H53ClN6O5S
CAS No.
SMILES

O=C(C1N(CCCC1)CC2=C(C=C(C(Cl)=C2)OCC3=C(C(C4=CC=CC=C4)=CC=C3)C)OCC5=CC(C#N)=CC=C5)NCCNC(CCCC[C@H]6[C@]7([H])[C@](NC(N7)=O)([H])CS6)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SWS1 Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SWS12922115-32-8SWS 1SWS-1PD-1/PD-L1Monoamine OxidasePD-1/Programmed death-ligand 1MAOBiotin conjugationTumor infiltrating lymphocyteB16-F10Inhibitorinhibitorinhibit

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