T-705RMP

Cat. No.: HY-136498: FAQs
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T-705RMP, a phosphorylated metabolite of T-705, exhibits a very weak inhibitory effect on the IMP dehydrogenase (IMPDH) activities of the host cells, with an IC₅₀ of 601 μM.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (T-705RMP ammonium) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

T-705RMP Chemical Structure

CAS No. : 356783-08-9

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Other Forms of T-705RMP:

T-705RMP ammonium Get quote

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Description	T-705RMP, a phosphorylated metabolite of T-705, exhibits a very weak inhibitory effect on the IMP dehydrogenase (IMPDH) activities of the host cells, with an IC₅₀ of 601 μM^[1].
In Vitro	T-705 can be converted to T-705RMP and T-705RTP by cellular kinases; Host cell enzymes can differentiate T-705, T-705RMP, and T-705RTP from the natural nucleotides. The level of inhibition of IMPDH by T-705RMP is about 150-fold weaker than that by Ribavirin monophosphate, and it became apparent that the antiviral effect of T-705 is not a result of the inhibition of the cellular enzyme^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. T-705RMP Related Antibodies
Molecular Weight	369.20
Formula	C₁₀H₁₃FN₃O₉P
CAS No.	356783-08-9
SMILES	O=C1N([C@@H]([C@H](O)[C@@H]2O)O[C@@H]2COP(O)(O)=O)C=C(F)N=C1C(N)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (270 KB) Handling Instructions (2659 KB)
References	[1]. Furuta Y, et al. Mechanism of action of T-705 against influenza virus. Antimicrob Agents Chemother. 2005;49(3):981‐986. [Content Brief]

T-705RMP Related Classifications

Infection

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

T-705RMP356783-08-9Drug MetabolitephosphorylatedmetaboliteIMPDHhostcellsInhibitorinhibitorinhibit

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