2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. T-Type calcium channel inhibitor 2

T-Type calcium channel inhibitor 2 (compound 6g) is a potent T-type calcium channel inhibitor with IC50s of 31.0, 83.1, 69.3 µM for Cav3.1 (α1G), Cav3.2 (α1H), Cav3.3 (α1I) (α1H), respectively. T-Type calcium channel inhibitor 2 shows cytotoxicity for A549, HCT-116 cells with IC50s of 5.0, 6.4 µM, respectively.

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T-Type calcium channel inhibitor 2 Chemical Structure

T-Type calcium channel inhibitor 2 Chemical Structure

CAS No. : 2771965-57-0

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T-Type calcium channel inhibitor 2 Related Antibodies

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Description

T-Type calcium channel inhibitor 2 (compound 6g) is a potent T-type calcium channel inhibitor with IC50s of 31.0, 83.1, 69.3 µM for Cav3.1 (α1G), Cav3.2 (α1H), Cav3.3 (α1I) (α1H), respectively. T-Type calcium channel inhibitor 2 shows cytotoxicity for A549, HCT-116 cells with IC50s of 5.0, 6.4 µM, respectively[1].

IC50 & Target[1]

CaV3.1

31.0 μM (IC50)

Cav3.2

83.1 μM (IC50)

CaV3.3

69.3 μM (IC50)

Molecular Weight

594.78

Formula

C36H39FN4OS
CAS No.
SMILES

CN(CCCCCSC1=NC2=CC=CC=C2C(N1C3=CC=C(C=C3)C4=CC=CC=C4)CC(NCC5=CC=C(C=C5)F)=O)C
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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T-Type calcium channel inhibitor 2 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

T-Type calcium channel inhibitor 22771965-57-0Calcium ChannelCa2+ channelsCa channelsanti-neoplasticA549HCT-116 cellscytotoxicity2-thio-3,4-dihydroquinazolineInhibitorinhibitorinhibit

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