2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. T-Type calcium channel inhibitor 2

T-Type calcium channel inhibitor 2 (compound 6g) is a potent T-type calcium channel inhibitor with IC50s of 31.0, 83.1, 69.3 µM for Cav3.1 (α1G), Cav3.2 (α1H), Cav3.3 (α1I) (α1H), respectively. T-Type calcium channel inhibitor 2 shows cytotoxicity for A549, HCT-116 cells with IC50s of 5.0, 6.4 µM, respectively.

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T-Type calcium channel inhibitor 2 Chemical Structure

T-Type calcium channel inhibitor 2 Chemical Structure

CAS No. : 2771965-57-0

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T-Type calcium channel inhibitor 2 Related Antibodies

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Description

T-Type calcium channel inhibitor 2 (compound 6g) is a potent T-type calcium channel inhibitor with IC50s of 31.0, 83.1, 69.3 µM for Cav3.1 (α1G), Cav3.2 (α1H), Cav3.3 (α1I) (α1H), respectively. T-Type calcium channel inhibitor 2 shows cytotoxicity for A549, HCT-116 cells with IC50s of 5.0, 6.4 µM, respectively[1].

IC50 & Target[1]

CaV3.1

31.0 μM (IC50)

Cav3.2

83.1 μM (IC50)

CaV3.3

69.3 μM (IC50)

Cellular Effect
Cell Line Type Value Description References
A549 IC50
5 μM
Compound: 6g
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 32327350]
HCT-116 IC50
6.4 μM
Compound: 6g
Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 32327350]
Molecular Weight

594.78

Formula

C36H39FN4OS
CAS No.
SMILES

CN(CCCCCSC1=NC2=CC=CC=C2C(N1C3=CC=C(C=C3)C4=CC=CC=C4)CC(NCC5=CC=C(C=C5)F)=O)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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T-Type calcium channel inhibitor 2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

T-Type calcium channel inhibitor 22771965-57-0Calcium ChannelCa2+ channelsCa channelsanti-neoplasticA549HCT-116 cellscytotoxicity2-thio-3,4-dihydroquinazolineInhibitorinhibitorinhibit

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