2. Apoptosis
  3. DAPK
  4. TAT-GluN2BCTM

TAT-GluN2BCTM is a membrane-permeable DAPK1-targeting peptide. TAT-GluN2BCTM targets active DAPK1 to lysosomes for degradation. TAT-GluN2BCTM protects neurons from oxidative stress and NMDAR-mediated excitotoxicity by knocking down DAPK1. TAT-GluN2BCTM can be used in the study of neuroprotection.

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TAT-GluN2BCTM Chemical Structure

TAT-GluN2BCTM Chemical Structure

CAS No. : 1587742-50-4

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TAT-GluN2BCTM Related Antibodies

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Description

TAT-GluN2BCTM is a membrane-permeable DAPK1-targeting peptide. TAT-GluN2BCTM targets active DAPK1 to lysosomes for degradation. TAT-GluN2BCTM protects neurons from oxidative stress and NMDAR-mediated excitotoxicity by knocking down DAPK1. TAT-GluN2BCTM can be used in the study of neuroprotection[1].

IC50 & Target

DAPK1[1].
In Vitro

TAT-GluN2BCTM (200 µM; 0.5, 2, 4 h) results in a time-dependent reduction in DAPK1 levels in NMDA-treated primary neuronal cultures [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TAT-GluN2BCTM Related Antibodies

Western Blot Analysis[1]

Cell Line: primary neuronal cultures (NMDA-treated)
Concentration: 200 µM
Incubation Time: 0.5, 2, 4 h
Result: Reduced DAPK1 levels in a time-dependent manner.
In Vivo

TAT-GluN2BCTM (10 mg/kg; i.v.; single) results in a significant reduction in DAPK1 levels only in the ischemic side of the brain in rats[1].
TAT-GluN2BCTM (10 mg/kg; i.v.; single) shows prominent neuroprotection in the cortex and striatum of rats[1].
TAT-GluN2BCTM is capable of specific knockdown of the active (but not inactive) form of DAPK1[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Focal ischemia rat model[1].
Dosage: 10 mg/kg
Administration: Intravenous injection; single.
Result: Reduced the levels of DAPK1 only in the ischemic side of the brain.
Significantly reduced the numbers of degenerating neurons in both striatum and cortical areas.
Molecular Weight

5135.91

Formula

C224H374N86O54
CAS No.
Sequence

Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Lys-Lys-Asn-Arg-Asn-Lys-Leu-Arg-Arg-Gln-His-Ser-Tyr-Lys-Phe-Glu-Arg-Gln-Lys-Ile-Leu-Asp-Gln-Arg-Phe-Phe-Glu
Sequence Shortening

YGRKKRRQRRRKKNRNKLRRQHSYKFERQKILDQRFFE
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TAT-GluN2BCTM Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TAT-GluN2BCTM1587742-50-4DAPKDeath associated protein kinaseDAPK1neurons protectionoxidative stressInhibitorinhibitorinhibit

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