Taurocholic acid-d₅ sodium 

Taurocholic acid-d₅ (sodium) is deuterium labeled Taurocholic acid (sodium). Taurocholic acid sodium (Sodium taurocholate) has marked bioactive effects such as an inhibitory potential against hepatic artery ligation induced biliary damage by upregulation of VEGF-A expression. Taurocholic acid sodium has immunoregulation effect^[1][2].

542.72

C₂₆H₃₉D₅NNaO₇S

145-42-6

O=C(CC[C@H]([C@@]1([C@]2([C@H](C[C@]3([C@@]([H])([C@@H](C[C@@]4(C([2H])([C@@]([2H])(C([2H])(C[C@@]43C)[2H])O)[2H])[H])O)[C@@]2(CC1)[H])[H])O)C)[H])C)NCCS(=O)(O[Na])=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. Xun Z,et al. Taurocholic acid inhibits the response to interferon-α therapy in patients with HBeAg-positive chronic hepatitis B by impairing CD8+ T and NK cell function. Cell Mol Immunol. 2021 Feb;18(2):461-471.  [Content Brief]

  [3]. Caiyun Wang, et al. Effects of taurocholic acid on immunoregulation in mice. Int Immunopharmacol. 2013 Feb;15(2):217-22.  [Content Brief]

  [4]. Glaser S, et al. Taurocholic acid prevents biliary damage induced by hepatic artery ligation in cholestatic rats. Dig Liver Dis. 2010 Oct;42(10):709-17.  [Content Brief]