TCS 401 free base

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TCS 401 free base is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B).

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TCS 401 free base Chemical Structure

CAS No. : 243967-42-2

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Other In-stock Forms of TCS 401 free base:

TCS 401

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TCS 401 In-stock

2 Publications Citing Use of MCE TCS 401 free base

: TCS 401 free base purchased from MedChemExpress. Usage Cited in: J Tissue Eng Regen Med. 2020 Apr;14(4):575-587. [Abstract]; The activation of Src by treatment with the 152RM peptide is reversed by pretreatment with the PTP1B inhibitor TCS-401, and the increased phosphorylation of β-catenin Y654 by treatment with the 152RM peptide is reduced by pretreatment with the Src inhibitor bosutinib.

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Description	TCS 401 free base is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B).
Molecular Weight	270.26
Formula	C₁₀H₁₀N₂O₅S
CAS No.	243967-42-2
SMILES	O=C(C(NC1=C(C(O)=O)C(CCNC2)=C2S1)=O)O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (270 KB) Handling Instructions (2659 KB)
References	[1]. Du ZD, et al. Protein tyrosine phosphatase 1B regulates the activity of retinal pigment epithelial cells. Mol Vis. 2015 May 1;21:523-31. [Content Brief] [2]. Ponnusamy M, et al. Necrotic renal epithelial cell inhibits renal interstitial fibroblast activation: role of protein tyrosine phosphatase 1B. Am J Physiol Renal Physiol. 2013 Mar 15;304(6):F698-709. [Content Brief]

TCS 401 free base Related Classifications

Metabolic Disease

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TCS 401243967-42-2TCS401TCS-401PhosphataseInhibitorinhibitorinhibit

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TCS 401 free base

Other Forms of TCS 401 free base:

TCS 401 free base Related Antibodies

2 Publications Citing Use of MCE TCS 401 free base

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