2. Stem Cell/Wnt
  3. YAP
  4. TEAD-IN-9

TEAD-IN-9 (compound 17) is a TEAD1 inhibitor with an IC50 of 0.29 μM. TEAD-IN-9 targets the palmitoyl pocket of TEAD, thereby effectively inhibiting the binding of YAP-TEAD and blocking the transcriptional function of YAP-TEAD.

For research use only. We do not sell to patients.

TEAD-IN-9 Chemical Structure

TEAD-IN-9 Chemical Structure

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TEAD-IN-9 Related Antibodies

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Description

TEAD-IN-9 (compound 17) is a TEAD1 inhibitor with an IC50 of 0.29 μM. TEAD-IN-9 targets the palmitoyl pocket of TEAD, thereby effectively inhibiting the binding of YAP-TEAD and blocking the transcriptional function of YAP-TEAD[1].

In Vivo


Pharmacokinetic Analysis in SD rats[1]

Route Dose (mg/kg) Cmax (ng/mL) Tmax (h) AUC0-t (ng·h/mL) AUC0-∞ (ng·h/mL) Vss (L/kg) Cl (L/h/kg) MRT0-t (h) MRT0-∞ (h) t1/2 (h) F (%)
i.g. 10 1477 0.5 4662 5688 / / 2.84 4.66 3.46 51.9
i.v. 1 598 / 899 924 1.947 1.082 1.55 1.80 1.94 51.9

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

477.42

Formula

C23H23F3N3O3P
SMILES

O=P(C)(C)C1=CC=C(NCC2=CC=C(C(F)(F)F)C=C2)C(C3=NC(OC4COC4)=CC=N3)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TEAD-IN-9 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TEAD-IN-9YAPYes-associated proteinTEAD1 inhibitorYAP-TEADtranscriptional functionInhibitorinhibitorinhibit

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HY-161443
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