1. Membrane Transporter/Ion Channel Neuronal Signaling
  2. nAChR
  3. Tebanicline

Tebanicline, an analogue of epibatidine, is a neuronal nicotinic acetylcholine receptor agonist. Tebanicline exhibits potent antinociceptive effects and has a high affinity for the α4β2 neuronal nicotinic acetylcholine receptor subunit in the central nervous system.

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Tebanicline Chemical Structure

Tebanicline Chemical Structure

CAS No. : 198283-73-7

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Description

Tebanicline, an analogue of epibatidine, is a neuronal nicotinic acetylcholine receptor agonist. Tebanicline exhibits potent antinociceptive effects and has a high affinity for the α4β2 neuronal nicotinic acetylcholine receptor subunit in the central nervous system.

Cellular Effect
Cell Line Type Value Description References
IMR-32 EC50
0.02 μM
Compound: tebeniciline
Agonist activity at human recombinant alpha4beta2 nAChR expressed in human IMR32 cells assessed as calcium dynamics by FLIPR assay
Agonist activity at human recombinant alpha4beta2 nAChR expressed in human IMR32 cells assessed as calcium dynamics by FLIPR assay
[PMID: 19232492]
IMR-32 EC50
0.19 μM
Compound: tebeniciline
Agonist activity at human recombinant alpha3beta4 nAChR expressed in human IMR32 cells assessed as calcium dynamics by FLIPR assay
Agonist activity at human recombinant alpha3beta4 nAChR expressed in human IMR32 cells assessed as calcium dynamics by FLIPR assay
[PMID: 19232492]
Molecular Weight

198.65

Formula

C9H11ClN2O

CAS No.
SMILES

ClC(C=C1)=NC=C1OC[C@@H]2NCC2

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Tebanicline
Cat. No.:
HY-14316
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