Teixobactin

Cat. No.: HY-P0230: FAQs
Data Sheet Handling Instructions Technical Support

Teixobactin is a potent antibiotic. Teixobactin shows antibacterial activity for gram-negative bacteria. Teixobactin inhibits cell wall synthesis by binding to a highly conserved motif of lipid II and lipid III.

For research use only. We do not sell to patients.

Teixobactin Chemical Structure

CAS No. : 1613225-53-8

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Teixobactin (0-128 µg/mL) shows antibacterial activity with a MIC value of 0.25 µg/mL for MRSA ATCC 33591^[2].
Teixobactin (0-24 h) shows antibacterial activity with MIC values of 5, 20 ng/mL for Clostridium difficile, Bacillus anthracis, respectively^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Teixobactin (1-20 mg/kg; i.v.; once) shows antibacterial activity in mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female CD-1 mice (MRSA ATCC33591)^[3]
Dosage:	1, 2.5, 5, 10, 20 mg/kg
Administration:	i.v.; once; one hour post-infection
Result:	Showed good antibacterial activity and all treated animals survived.

Molecular Weight

1242.47

Formula

C₅₈H₉₅N₁₅O₁₅

CAS No.

1613225-53-8

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Piddock LJ. Teixobactin, the first of a new class of antibiotics discovered by iChip technology? J Antimicrob Chemother. 2015 Oct;70(10):2679-80. [Content Brief]

[2]. Parmar A, et al. Teixobactin analogues reveal enduracididine to be non-essential for highly potent antibacterial activity and lipid II binding. Chem Sci. 2017 Dec 1;8(12):8183-8192. [Content Brief]

[3]. Ling LL, et al. A new antibiotic kills pathogens without detectable resistance. Nature. 2015 Jan 22;517(7535):455-9. [Content Brief]

Teixobactin Related Classifications

Infection

Molarity Calculator
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Teixobactin1613225-53-8AntibioticBacterialgram-negative bacteriaantibacterialcell wallpeptidoglycanInhibitorinhibitorinhibit

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