Tetracycline-d₆-1 

Tetracycline-d₆-1 is deuterated labeled 2-Isobutyl-3-methoxypyrazine (HY-W017141). 2-Isobutyl-3-methoxypyrazine is an aroma constituent in grapes andwines, green pepper and asparagus^[1].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].
Tetracycline shows susceptibilfty of V. vulnlflcus strain B3547 with MIC value of 0.5 g/mL^[3].
Tetracycline inhibits the L-amyloid aggregates formation and disassembles the pre-formed fibrils^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tetracycline (3 mg/kg; i.p. every 12 h until survive) survives mice from bacteremia^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

450.47

C₂₂H₁₈D₆N₂O₈

60-54-8

[H][C@]12C[C@]3([C@@H](C(C(C(N)=O)=C([C@]3(C(C1=C(C4=C([C@]2(O)C)C=CC=C4O)O)=O)O)O)=O)N(C([2H])([2H])[2H])C([2H])([2H])[2H])[H]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. Chopra I, et al. Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology ofbacterial resistance. Microbiol Mol Biol Rev. 2001 Jun;65(2):232-60.  [Content Brief]

  [3]. Bowdre JH, et al. Antibiotic efficacy against Vibrio vulnificus in the mouse: superiority of tetracycline. J Pharmacol Exp Ther. 1983 Jun;225(3):595-8.  [Content Brief]

  [4]. Forloni G, et al. Anti-amyloidogenic activity of tetracyclines: studies in vitro. FEBS Lett. 2001 Jan 5;487(3):404-7.  [Content Brief]