Tetrindole mesylate 

Tetrindole mesylate is a selective inhibitor of monoamine oxidase A (MAO A). Tetrindole mesylate inhibits rat brain mitochondrial MAO A in a competitive manner with a K_i value of 0.4 μM and inhibits MAO B with a K_i of 110 μM. Tetrindole mesylate has antidepressant activity^[1][2].

Tetrindole mesylate has IC₅₀s of 0.51-1.37 μM for 6 human breast tumor cell lines (MCF-7, HCC1954, T47D, MDA-MB-157, ZR75-1, BT474)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tetrindole mesylate (25 mg/kg; po; single dose) inhibits rat brain and liver mitochondrial MAO A by 80% within 0.5-1 hr and the onset of recovery of enzyme activity became evident after 24 hr in male albino rats weighing 180-200 g^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

390.54

C₂₁H₃₀N₂O₃S

170964-68-8

Solid

White to off-white

CS(=O)(O)=O.N12C3=C(C4=C1C(NCC2)CCC4)C=C(C5CCCCC5)C=C3

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. A E Medvedev, et al. Monoamine oxidase inhibition by novel antidepressant tetrindole. Biochem Pharmacol. 1994 Jan 20;47(2):303-8.  [Content Brief]

  [2]. William D Gwynne, et al. Monoamine oxidase-A activity is required for clonal tumorsphere formation by human breast tumor cells. Cell Mol Biol Lett. 2019 Nov 12;24:59.  [Content Brief]