2. TGF-beta/Smad
  3. TGF-β Receptor
  4. TGFβRI-IN-7

TGFβRI-IN-7 (compound 16W) is a potent inhibitor of TGFβRI. TGFβRI-IN-7 inhibits SMAD2/3 phosphorylation and H22 cell viability with IC50 values of 12 and 65 nM, respectively. TGFβRI-IN-7 shows anti-tumor efficacy in a xenograft model of H22 cells, with TGI of 79.6 %.

For research use only. We do not sell to patients.

TGFβRI-IN-7 Chemical Structure

TGFβRI-IN-7 Chemical Structure

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TGFβRI-IN-7 Related Antibodies

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Description

TGFβRI-IN-7 (compound 16W) is a potent inhibitor of TGFβRI. TGFβRI-IN-7 inhibits SMAD2/3 phosphorylation and H22 cell viability with IC50 values of 12 and 65 nM, respectively. TGFβRI-IN-7 shows anti-tumor efficacy in a xenograft model of H22 cells, with TGI of 79.6 %[1].

Molecular Weight

472.58

Formula

C27H32N6O2
SMILES

CN(CCN1C=C(C=N1)C2=CC3=NC=CC(OC4=CN(N=C4C5CCOCC5)C6CC6)=C3C=C2)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TGFβRI-IN-7 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TGFβRI-IN-7TGF-β ReceptorTransforming growth factor beta receptorsxenograft model of H22 cellsInhibitorinhibitorinhibit

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