1. GPCR/G Protein
  2. G protein-coupled Bile Acid Receptor 1
  3. TGR5 agonist 6

TGR5 agonist 6 (compund 22b) is a non-systemic gut-targeted TGR5 agonist with significant and sustained blood sugar-lowering effects and an acceptable safety profile.

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TGR5 agonist 6 Chemical Structure

TGR5 agonist 6 Chemical Structure

CAS No. : 2925211-47-6

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Description

TGR5 agonist 6 (compund 22b) is a non-systemic gut-targeted TGR5 agonist with significant and sustained blood sugar-lowering effects and an acceptable safety profile[1].

IC50 & Target

TGR5[1]

Molecular Weight

803.77

Formula

C42H48Cl2N6O6

CAS No.
SMILES

O=C(N1CCCCCC(NCCCCCCNC(CCC(C=C2Cl)=C(C=C2OC3=C(C=NC=C3)C(N4CCN(C5=C4C=CC=C5)C6CC6)=O)Cl)=O)=O)C=CC1=O

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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
TGR5 agonist 6
Cat. No.:
HY-168140
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