2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. Thalidomide-benzylamine-Py-NH2

Thalidomide-benzylamine-Py-NH2 is a conjugate of E3 ligase ligand and linker, which is consisted of a Thalidomide (HY-14658) and the Linker Boc-NHCH2-Ph-Py-NH2 (HY-161496). Thalidomide-benzylamine-Py-NH2 is utilized for synthesis of PROTAC molecule XYD190 (HY-161494).

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Thalidomide-benzylamine-Py-NH2 Chemical Structure

Thalidomide-benzylamine-Py-NH2 Chemical Structure

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Thalidomide-benzylamine-Py-NH2 Related Antibodies

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Description

Thalidomide-benzylamine-Py-NH2 is a conjugate of E3 ligase ligand and linker, which is consisted of a Thalidomide (HY-14658) and the Linker Boc-NHCH2-Ph-Py-NH2 (HY-161496). Thalidomide-benzylamine-Py-NH2 is utilized for synthesis of PROTAC molecule XYD190 (HY-161494)[1].

Molecular Weight

455.47

Formula

C25H21N5O4
SMILES

NC1=CC=C(N=C1)C2=CC=C(C=C2)CNC3=CC=CC(C(N4C5C(NC(CC5)=O)=O)=O)=C3C4=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Thalidomide-benzylamine-Py-NH2 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thalidomide-benzylamine-Py-NH2E3 Ligase Ligand-Linker ConjugatesThalidomideAMLNOD-SCID miceMV4;11MOLM-13MOLM-16leukemiaInhibitorinhibitorinhibit

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HY-161497
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