2. PROTAC
  3. Ligands for E3 Ligase
  4. Thalidomide-NH-(CH2)2-NH-Boc

Thalidomide-NH-(CH2)2-NH-Boc is a Boc-modified Thalidomide (HY-14658) that acts as a Cereblon ligand to recruit CRBN protein. The Boc protecting group at the end of Thalidomide-NH-(CH2)2-NH-Boc can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-NH-(CH2)2-NH-Boc is a key intermediate in the synthesis of CRBN-based PROTAC molecules.

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Thalidomide-NH-(CH2)2-NH-Boc Chemical Structure

Thalidomide-NH-(CH2)2-NH-Boc Chemical Structure

CAS No. : 1957235-57-2

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Thalidomide-NH-(CH2)2-NH-Boc Related Antibodies

Top Publications Citing Use of Products

View All Ligands for E3 Ligase Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1

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Description

Thalidomide-NH-(CH2)2-NH-Boc is a Boc-modified Thalidomide (HY-14658) that acts as a Cereblon ligand to recruit CRBN protein. The Boc protecting group at the end of Thalidomide-NH-(CH2)2-NH-Boc can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-NH-(CH2)2-NH-Boc is a key intermediate in the synthesis of CRBN-based PROTAC molecules.

Molecular Weight

416.43

Formula

C20H24N4O6
CAS No.
SMILES

O=C(OC(C)(C)C)NCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Thalidomide-NH-(CH2)2-NH-Boc Related Classifications

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Keywords:

Thalidomide-NH-(CH2)2-NH-Boc1957235-57-2Ligands for E3 LigaseE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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