1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. Thioetheramide-PC

Thioetheramide-PC  (Synonyms: 1-Palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphorylcholine)

Cat. No.: HY-133233
Data Sheet Handling Instructions

Thioetheramide-PC is a structurally modified phospholipid that functions as a competitive, reversible inhibitor of secretory phospholipase A2 (sPLA2). The IC50 value for thioetheramide-PC is 2 μM at a substrate concentration of 0.5 mM.1 In addition to binding to the catalytic site of sPLA2, thioetheramide-PC also binds to the activator site of this enzyme. The binding of thioetheramide-PC to the activator site is tighter than its binding to the catalytic site. The result of this dual interaction is that at low concentrations thioetheramide-PC may activate phospholipase activity rather than inhibiting it.

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Thioetheramide-PC Chemical Structure

Thioetheramide-PC Chemical Structure

CAS No. : 116457-99-9

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Description

Thioetheramide-PC is a structurally modified phospholipid that functions as a competitive, reversible inhibitor of secretory phospholipase A2 (sPLA2). The IC50 value for thioetheramide-PC is 2 μM at a substrate concentration of 0.5 mM.1 In addition to binding to the catalytic site of sPLA2, thioetheramide-PC also binds to the activator site of this enzyme. The binding of thioetheramide-PC to the activator site is tighter than its binding to the catalytic site. The result of this dual interaction is that at low concentrations thioetheramide-PC may activate phospholipase activity rather than inhibiting it.

Molecular Weight

735.14

Formula

C40H83N2O5PS

CAS No.
SMILES

CCCCCCCCCCCCCCCCSC[C@@H](NC(CCCCCCCCCCCCCCC)=O)COP(OCC[N+](C)(C)C)([O-])=O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Thioetheramide-PC Related Classifications

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Thioetheramide-PC
Cat. No.:
HY-133233
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