THPN

Cat. No.: HY-113827 Purity: 98.00%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

THPN is a potent Nur77 agonist. THPN specifically binds the LBD of Nur77 (TR3) but not that of retinoic acid receptor α and PPARγ with a K_d of 270 nM. THPN leads to Nur77 translocation to the mitochondria to induce autophagic cell death in melanoma.

For research use only. We do not sell to patients.

THPN Chemical Structure

CAS No. : 100079-26-3

Size	Price	Stock
5 mg		Ask For Quote & Lead Time

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

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Nurr1/NR4A2 Nur77/NR4A1

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Nur77/NR4A1

Cellular Effect

Cell Line	Type	Value	Description	References
CCRF-CEM	IC₅₀	43 μM Compound: 8	Cytotoxicity against human CEM cells after 72 hrs by MTT assay Cytotoxicity against human CEM cells after 72 hrs by MTT assay	[PMID: 18295493]
CCRF-CEM	IC₅₀	50 μM Compound: 8	Cytotoxicity against human CEM cells after 24 hrs by MTT assay Cytotoxicity against human CEM cells after 24 hrs by MTT assay	[PMID: 18295493]
L1210	IC₅₀	22 μM Compound: 8	Cytotoxicity against mouse L1210 cells after 48 hrs by MTT assay Cytotoxicity against mouse L1210 cells after 48 hrs by MTT assay	[PMID: 18295493]
L1210	IC₅₀	22 μM Compound: 8	Cytotoxicity against mouse L1210 cells after 72 hrs by MTT assay Cytotoxicity against mouse L1210 cells after 72 hrs by MTT assay	[PMID: 18295493]

Molecular Weight

266.33

Formula

C₁₅H₂₂O₄

CAS No.

100079-26-3

Appearance

Solid

Color

White to off-white

SMILES

CCCCCCCCC(C1=CC(O)=C(O)C(O)=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL (93.87 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.7547 mL	18.7737 mL	37.5474 mL
5 mM	0.7509 mL	3.7547 mL	7.5095 mL
10 mM	0.3755 mL	1.8774 mL	3.7547 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

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Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.00%

Select Batch:

Data Sheet (274 KB) SDS (392 KB)

COA (243 KB)

Handling Instructions (2659 KB)

References

[1]. Wei-jia Wang, et al. Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. Nat Chem Biol. 2014 Feb;10(2):133-40. [Content Brief]

[2]. Li Li, et al. Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation. Nat Chem Biol. 2015 May;11(5):339-46. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.7547 mL	18.7737 mL	37.5474 mL	93.8685 mL
	5 mM	0.7509 mL	3.7547 mL	7.5095 mL	18.7737 mL
	10 mM	0.3755 mL	1.8774 mL	3.7547 mL	9.3869 mL
	15 mM	0.2503 mL	1.2516 mL	2.5032 mL	6.2579 mL
	20 mM	0.1877 mL	0.9387 mL	1.8774 mL	4.6934 mL
	25 mM	0.1502 mL	0.7509 mL	1.5019 mL	3.7547 mL
	30 mM	0.1252 mL	0.6258 mL	1.2516 mL	3.1290 mL
	40 mM	0.0939 mL	0.4693 mL	0.9387 mL	2.3467 mL
	50 mM	0.0751 mL	0.3755 mL	0.7509 mL	1.8774 mL
	60 mM	0.0626 mL	0.3129 mL	0.6258 mL	1.5645 mL
	80 mM	0.0469 mL	0.2347 mL	0.4693 mL	1.1734 mL

THPN Related Classifications

Inflammation/Immunology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

THPN100079-26-3Nuclear Hormone Receptor 4A/NR4ANerve Growth Factor IB-like Receptormelanoma cellNur77TR3Inhibitorinhibitorinhibit

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THPN

THPN Related Antibodies

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