2. Academic Validation
  3. Ester derivatives of gallic acid with potential toxicity toward L1210 leukemia cells

Ester derivatives of gallic acid with potential toxicity toward L1210 leukemia cells

  • Bioorg Med Chem. 2008 Apr 1;16(7):3791-9. doi: 10.1016/j.bmc.2008.01.049.
Claudriana Locatelli 1,  Rober Rosso,  Maria C Santos-Silva,  Camila A de Souza,  Marley A Licínio,  Paulo Leal,  Maria L Bazzo,  Rosendo A Yunes,  Tânia B Creczynski-Pasa
Affiliations

Affiliation

  • 1 Departamentos de Ciências Farmacêuticas, Universidade Federal de Santa Catarina, CP 476 Florianópolis, 88040-900 SC, Brazil.
PMID: 18295493 DOI: 10.1016/j.bmc.2008.01.049
Abstract

Gallic acid and gallates with the same number of hydroxyl groups and varying the length of the side carbon chain, with respective lipophilicity being defined through the ClogP values, were examined for their ability to induce Apoptosis (through the DNA ladder fragmentation pattern), mitochondrial and cytoplasmic GSH depletion and NF-kappaB activation in murine lymphoblastic L1210 leukemia cells. A relationship between cytotoxic effect and a limited degree of lipophilicity was observed.

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