1. Membrane Transporter/Ion Channel Neuronal Signaling
  2. Sigma Receptor Potassium Channel iGluR
  3. threo-Ifenprodil hemitartrate

threo Ifenprodil hemitartrate is a σ receptor agonist, with Kis of 59.1 and 2 nM for σ1 and σ2 receptors, respectively. threo Ifenprodil hemitartrate is also a NR2B subunit-selective NMDA receptor antagonist (IC50=0.22 μM). threo Ifenprodil hemitartrate is a hERG potassium channel inhibitor, with an IC 50 of 88 nM, showing antiarrhythmic activity.

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threo-Ifenprodil hemitartrate Chemical Structure

threo-Ifenprodil hemitartrate Chemical Structure

CAS No. : 1312991-83-5

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Description

threo Ifenprodil hemitartrate is a σ receptor agonist, with Kis of 59.1 and 2 nM for σ1 and σ2 receptors, respectively. threo Ifenprodil hemitartrate is also a NR2B subunit-selective NMDA receptor antagonist (IC50=0.22 μM). threo Ifenprodil hemitartrate is a hERG potassium channel inhibitor, with an IC 50 of 88 nM, showing antiarrhythmic activity[1][2][3].

IC50 & Target

IC50: 0.22 μM (NMDA)[1].

Molecular Weight

400.50

Formula

C21H27NO2.1/2C4H6O6

CAS No.
SMILES

OC([C@H](O)[C@@H](O)C(O)=O)=O.O[C@H](C1=CC=C(C=C1)O)[C@@H](C)N(CC2)CCC2CC3=CC=CC=C3.[1/2]

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
threo-Ifenprodil hemitartrate
Cat. No.:
HY-107708
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