2. Membrane Transporter/Ion Channel
  3. Proton Pump
  4. Tiludronate disodium

Tiludronate disodium  (Synonyms: Tiludronic acid disodium)

Cat. No.: HY-A0213A Purity: 99.84%
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Tiludronate (Tiludronic Acid) disodium, an orally active bisphosphonate, can act an osteoregulator. Tiludronate is used for the research of the metabolic bone disorders. Tiludronate is a potent inhibitor of the osteoclast vacuolar H(+)-ATPase. Antiresorptive and anti-inflammatory properties.

For research use only. We do not sell to patients.

Tiludronate disodium Chemical Structure

Tiludronate disodium Chemical Structure

CAS No. : 149845-07-8

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Based on 1 publication(s) in Google Scholar

Other Forms of Tiludronate disodium:

Tiludronate disodium Related Antibodies

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1 Publications Citing Use of MCE Tiludronate disodium

  • Biological Activity

  • Purity & Documentation

  • References

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Description

Tiludronate (Tiludronic Acid) disodium, an orally active bisphosphonate, can act an osteoregulator. Tiludronate is used for the research of the metabolic bone disorders. Tiludronate is a potent inhibitor of the osteoclast vacuolar H(+)-ATPase. Antiresorptive and anti-inflammatory properties[1][2][3][4].

In Vitro

The ability of Tiludronate to inhibit proton transport is 5-fold higher in kidney-derived vesicles (IC50=1.1 mM) and 10,000-fold higher in vesicles derived from osteoclasts (IC50=466 nM). Tiludronate also potently inhibits proton transport in yeast microsomal preparations (IC50=3.5 microM) and inhibits the activity of purified yeast V-ATPase. The inhibition of the osteoclast V-ATPase-mediated proton transport by Tiludronate is rapid, pH-dependent, and reversible[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tiludronate disodium Related Antibodies
In Vivo

Tiludronate exerts a dose-dependent inhibitory activity on bone resorption. Tiludronate could act on mature osteoclasts by reducing their capacity to secrete proton into the resorption space and also by favoring their detachment from the bone matrix. Tiludronate is also tested in other models of osteoporosis. In the castrated male rat model, Tiludronate (5-200 mg/kg; p.o.) prevents the decrease in the skeletal mass, assessed physically by measuring the bone weight and density or chemically by determining the calcium and phosphate content[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

362.57

Formula

C7H7ClNa2O6P2S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=P(O)(O[Na])C(P(O)(O[Na])=O)SC1=CC=C(Cl)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 62.5 mg/mL (172.38 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7581 mL 13.7904 mL 27.5809 mL
5 mM 0.5516 mL 2.7581 mL 5.5162 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.84%

SDS (615 KB)

COA (252 KB) HNMR (262 KB) LCMS (96 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.7581 mL 13.7904 mL 27.5809 mL 68.9522 mL
5 mM 0.5516 mL 2.7581 mL 5.5162 mL 13.7904 mL
10 mM 0.2758 mL 1.3790 mL 2.7581 mL 6.8952 mL
15 mM 0.1839 mL 0.9194 mL 1.8387 mL 4.5968 mL
20 mM 0.1379 mL 0.6895 mL 1.3790 mL 3.4476 mL
25 mM 0.1103 mL 0.5516 mL 1.1032 mL 2.7581 mL
30 mM 0.0919 mL 0.4597 mL 0.9194 mL 2.2984 mL
40 mM 0.0690 mL 0.3448 mL 0.6895 mL 1.7238 mL
50 mM 0.0552 mL 0.2758 mL 0.5516 mL 1.3790 mL
60 mM 0.0460 mL 0.2298 mL 0.4597 mL 1.1492 mL
80 mM 0.0345 mL 0.1724 mL 0.3448 mL 0.8619 mL
100 mM 0.0276 mL 0.1379 mL 0.2758 mL 0.6895 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Tiludronate disodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tiludronate disodium149845-07-8Tiludronic acid disodiumProton PumporalbisphosphonateinflammatoryV-ATPaseosteoporosisyeastInhibitorinhibitorinhibit

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