TIM-063

Cat. No.: HY-148757 Purity: 96.63%: FAQs
Data Sheet SDS COA Handling Instructions

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TIM-063 is a selective and cell-permeable CaMKK inhibitor, ATP competitive inhibitor, can directly target the catalytic domain of CaMKK, with the K_i values of 0.35 μM and 0.2 μM for CaMKKα and CaMKKβ, respectively, the IC₅₀ values are 0.63 μM and 0.96 μM, respectively.

For research use only. We do not sell to patients.

TIM-063 Chemical Structure

CAS No. : 2493978-38-2

Size	Price	Stock	Quantity
5 mg	USD 340	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 550	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1100	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1760	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 2820	Get quote	Estimated Time of Arrival: December 31
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Description	TIM-063 is a selective and cell-permeable CaMKK inhibitor, ATP competitive inhibitor, can directly target the catalytic domain of CaMKK, with the K_i values of 0.35 μM and 0.2 μM for CaMKKα and CaMKKβ, respectively, the IC₅₀ values are 0.63 μM and 0.96 μM, respectively^[1].
In Vitro	TIM-063 (0-29 μM, 6 h) dose-dependently inhibits endogenous CaMKK activity in HeLa cells and also inhibits CaMKK isoform-catalyzed phosphorylation of CaMKIV in transfected COS-7 cells^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. TIM-063 Related Antibodies
Molecular Weight	331.28
Formula	C₁₈H₉N₃O₄
CAS No.	2493978-38-2
Appearance	Solid
Color	Light yellow to brown
SMILES	O=C1C2=CC=CC3=C([N+]([O-])=O)C(O)=CC(C4=NC5=C(N14)C=CC=C5)=C32
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	4°C, protect from light, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Purity & Documentation	Purity: 96.63% Select Batch: Data Sheet (273 KB) SDS (251 KB) COA (257 KB) HNMR (259 KB) RP-HPLC (247 KB) LCMS (106 KB) Handling Instructions (2659 KB)
References	[1]. Satomi Ohtsuka, et al. Development and Characterization of Novel Molecular Probes for Ca2+/Calmodulin-Dependent Protein Kinase Kinase, Derived from STO-609. Biochemistry. 2020 May 5;59(17):1701-1710. [Content Brief]

TIM-063 Related Classifications

Metabolic Disease

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TIM-0632493978-38-2TIM063TIM 063CaMKCalmodulin-dependent protein kinasesCalmodulin-dependent kinasesCaMKKATPCaMKKαCaMKKβInhibitorinhibitorinhibit

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