2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. TLR7/8/9 antagonist 2

TLR7/8/9 antagonist 2 is an orally active TLR7/8/9 antagonist. TLR7/8/9 antagonist 2 has inhibitory activities for HEK/hTLR7, HEK/hTLR8 and HEK/hTLR9 with IC50 values of 0.011 μM, 0.029 μM and 0,052 μM, respectively.TLR7/8/9 antagonist 2 has high bioavailability in vivo.TLR7/8/9 antagonist 2 can be used for the research of auto-inflammatory diseases such as systemic lupus erythematosus or lupus nephritis.

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TLR7/8/9 antagonist 2 Chemical Structure

TLR7/8/9 antagonist 2 Chemical Structure

CAS No. : 2920729-91-3

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TLR7/8/9 antagonist 2 Related Antibodies

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Description

TLR7/8/9 antagonist 2 is an orally active TLR7/8/9 antagonist. TLR7/8/9 antagonist 2 has inhibitory activities for HEK/hTLR7, HEK/hTLR8 and HEK/hTLR9 with IC50 values of 0.011 μM, 0.029 μM and 0,052 μM, respectively.TLR7/8/9 antagonist 2 has high bioavailability in vivo.TLR7/8/9 antagonist 2 can be used for the research of auto-inflammatory diseases such as systemic lupus erythematosus or lupus nephritis[1].

IC50 & Target

IC50: 0.011 μM (HEK/hTLR7); 0.029 μM (HEK/hTLR8); 0.052 μM (HEK/hTLR9); 420 nM (hPBMC/TLR9)[1].
In Vitro

TLR7/8/9 antagonist 2 (example 7) has inhibitory activities for HEK/hTLR7, HEK/hTLR8 and HEK/hTLR9 with IC50 values of 0.011 μM, 0.029 μM and 0,052 μM, respectively[1].
TLR7/8/9 antagonist 2 has inhibitory activities for hPBMC/TLR9 with IC50 value of 420 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TLR7/8/9 antagonist 2 Related Antibodies
In Vivo

TLR7/8/9 antagonist 2 (example 7) has high bioavailability in vivo[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wister-Han Rats[1]
Dosage: 2 mg/kg, 10 mg/kg
Administration: p.o., i.v.; single dose
Result:
PO Cmax(ng/mL) PO AUC0-last(h*ng/mL) IV AUC0-last(h*ng/mL) CL (mL/min/kg) Vss (L/kg) T1/2(h) F(%)
465 7514 1516 16 16.8 14.7 100
Molecular Weight

405.54

Formula

C23H31N7
CAS No.
SMILES

CN1N=CC2=C(C=C(C)N=C21)N(CC3)CCC3C4=NC=C(N5CCNCC5)C=C4C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TLR7/8/9 antagonist 2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TLR7/8/9 antagonist 22920729-91-3Toll-like Receptor (TLR)TLR7/8/9auto-inflammatory diseasessystemic lupus erythematosuslupus nephritisInhibitorinhibitorinhibit

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