2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. TLR7/8 agonist 8

TLR7/8 agonist 8 (compound 24m) is a potent toll-like receptor 7/8 (TLR7/8) dual agonist, with EC50s of 27 and 12 nM for hTLR7 and hTLR8, respectively. TLR7/8 agonist 8 can improve the antitumor activity of PD-1/PD-L1 blockade.

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TLR7/8 agonist 8 Chemical Structure

TLR7/8 agonist 8 Chemical Structure

CAS No. : 2649170-16-9

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TLR7/8 agonist 8 Related Antibodies

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Description

TLR7/8 agonist 8 (compound 24m) is a potent toll-like receptor 7/8 (TLR7/8) dual agonist, with EC50s of 27 and 12 nM for hTLR7 and hTLR8, respectively. TLR7/8 agonist 8 can improve the antitumor activity of PD-1/PD-L1 blockade[1].

IC50 & Target[1]

TLR7

27 nM (EC50)

TLR8

12 nM (EC50)

Molecular Weight

418.53

Formula

C24H30N6O
CAS No.
SMILES

CCCCNC1=C2N=C(CC3=CC=C(CN4CC5(C4)COC5)C=C3)C=CC2=NC(N)=N1
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Purity & Documentation
References
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TLR7/8 agonist 8 Related Classifications

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Keywords:

TLR7/8 agonist 82649170-16-9Toll-like Receptor (TLR)antitumor activityPD-1PD-L1Inhibitorinhibitorinhibit

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