2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. TLR7 agonist 20

TLR7 agonist 20 (compound 23) is an imidazoquinoline analogue. TLR7 agonist 20 is a potent TLR7 specific agonist, with an EC50 value of 0.23 μM for hTLR7. TLR7 agonist 20 shows strong adjuvant activity on spike antibody levels which induces a strong T helper 1 (Th1) response with increase in IgG2b and IgG2c, in addition to IgG1.

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TLR7 agonist 20 Chemical Structure

TLR7 agonist 20 Chemical Structure

CAS No. : 3029695-00-6

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TLR7 agonist 20 Related Antibodies

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Description

TLR7 agonist 20 (compound 23) is an imidazoquinoline analogue. TLR7 agonist 20 is a potent TLR7 specific agonist, with an EC50 value of 0.23 μM for hTLR7. TLR7 agonist 20 shows strong adjuvant activity on spike antibody levels which induces a strong T helper 1 (Th1) response with increase in IgG2b and IgG2c, in addition to IgG1[1].

IC50 & Target

TLR7

0.23 μM (EC50)

TLR8

17.21 μM (EC50)

Molecular Weight

360.45

Formula

C22H24N4O
CAS No.
SMILES

CCCCC1=NC2=C(C3=CC=CC=C3N=C2N)N1CC4=CC=C(C=C4)CO
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TLR7 agonist 20 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TLR7 agonist 203029695-00-6Toll-like Receptor (TLR)adjuvant activityIMDQimidazoquinolinespike proteinInhibitorinhibitorinhibit

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