2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. TLR7 agonist 21

TLR7 agonist 21 (Compound 27B) is a selective agonist for Toll-like receptor 7(TLR7), with an EC50 of 17.53 nM (for human TLR7) and 41.7 nM (for mouse TLR7). TLR7 agonist 21 stimulates the secretion of pro-inflammatory cytokines, such as IL-6, TNF-α, IFN-α1, and IL-4. TLR7 agonist 21 acts as a vaccine adjuvant, increases levels of IgG and IgA, and protects the mouse from influenza virus infections.

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TLR7 agonist 21 Chemical Structure

TLR7 agonist 21 Chemical Structure

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TLR7 agonist 21 Related Antibodies

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Description

TLR7 agonist 21 (Compound 27B) is a selective agonist for Toll-like receptor 7(TLR7), with an EC50 of 17.53 nM (for human TLR7) and 41.7 nM (for mouse TLR7). TLR7 agonist 21 stimulates the secretion of pro-inflammatory cytokines, such as IL-6, TNF-α, IFN-α1, and IL-4. TLR7 agonist 21 acts as a vaccine adjuvant, increases levels of IgG and IgA, and protects the mouse from influenza virus infections[1].

IC50 & Target

human TLR7

17.53 nM (EC50)

mTLR7

41.7 nM (EC50)

TLR8

5932 nM (EC50)

Molecular Weight

411.54

Formula

C22H33N7O
SMILES

NC1=NC2=C(C(NCCCC)=N1)N(C=N2)CC3=CC=C(C=C3OC)CN(CC)CC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TLR7 agonist 21 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TLR7 agonist 21Toll-like Receptor (TLR)vaccine adjuvantselectiveinfluenza virusH1N1H3N2BALB/c mouseInhibitorinhibitorinhibit

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