2. NF-κB Immunology/Inflammation Apoptosis
  3. IKK Interleukin Related TNF Receptor RIP kinase
  4. TNF-α-IN-19

TNF-α-IN-19 is an inhibitor of TNFα that can block the interaction between TNFαRI, TRADD, and RIP1, the EC50 values for TNFα, IL-1β, and IL-1β/TNFα are 2.451, 3.792 and 1.54 μM, respectively. TNF-α-IN-19 only inhibits the degradation of IκBα when cells are stimulated by TNFα and not by IL-1β.

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TNF-α-IN-19 Chemical Structure

TNF-α-IN-19 Chemical Structure

CAS No. : 338773-13-0

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TNF-α-IN-19 Related Antibodies

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Description

TNF-α-IN-19 is an inhibitor of TNFα that can block the interaction between TNFαRI, TRADD, and RIP1, the EC50 values for TNFα, IL-1β, and IL-1β/TNFα are 2.451, 3.792 and 1.54 μM, respectively. TNF-α-IN-19 only inhibits the degradation of IκBα when cells are stimulated by TNFα and not by IL-1β[1].

IC50 & Target

IL-1β

 

Molecular Weight

348.71

Formula

C16H8ClF3N4
CAS No.
SMILES

ClC1=CC=C(C2=NN=C3N2C4=C(N=C3C(F)(F)F)C=CC=C4)C=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TNF-α-IN-19 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TNF-α-IN-19338773-13-0IKKInterleukin RelatedTNF ReceptorRIP kinaseIκB kinaseI kappa B kinase ILTumor Necrosis Factor ReceptorTNFRReceptor-interacting protein kinasesRIPKTNFαIκBαIL-1βInhibitorinhibitorinhibit

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