2. Cell Cycle/DNA Damage Epigenetics
  3. PARP
  4. TNKS1/2-IN-2

TNKS1/2-IN-2 (Compound 21) is a potent and selective tankyrases inhibitor. TNKS1/2-IN-2 exhibits IC50 values of 4 nM and 63 nM against TNK1 and TNK2 in the enzymatic assay, respectively. TNKS1/2-IN-2 inhibits proliferation of A549 and H292 cell lines with IC50 values of 39.5 nM and 12.8 nM, respectively. TNKS1/2-IN-2 can be used for the research of cancer.

For research use only. We do not sell to patients.

TNKS1/2-IN-2 Chemical Structure

TNKS1/2-IN-2 Chemical Structure

CAS No. : 1498300-35-8

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TNKS1/2-IN-2 Related Antibodies

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Description

TNKS1/2-IN-2 (Compound 21) is a potent and selective tankyrases inhibitor. TNKS1/2-IN-2 exhibits IC50 values of 4 nM and 63 nM against TNK1 and TNK2 in the enzymatic assay, respectively. TNKS1/2-IN-2 inhibits proliferation of A549 and H292 cell lines with IC50 values of 39.5 nM and 12.8 nM, respectively. TNKS1/2-IN-2 can be used for the research of cancer[1].
IC50 & Target

IC50: 4 nM (TNK1); 63 nM (TNK2); 39.5 nM (A549 cell); 12.8 nM (H292 cell)[1].
Molecular Weight

499.48

Formula

C26H24F3N3O4
CAS No.
SMILES

O=C(N(C1=O)C[C@@H]2CC[C@H](CC2)C(O)=O)C(C(N1CC3=C(C(C(F)(F)F)=CC=C3)C#N)=CC=C4)=C4C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TNKS1/2-IN-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TNKS1/2-IN-21498300-35-8PARPpoly ADP ribose polymerasetankyrasesTNK1TNK2A549 cellH292 cellcancerInhibitorinhibitorinhibit

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