Trihydroxycholestanoic acid (Synonyms: Coprocholic acid)

Cat. No.: HY-113335 Purity: 98.75%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Trihydroxycholestanoic acid is an endogenous metabolite present in Blood that can be used for the research of Zellweger Syndrome, Refsum Disease, D Bifunctional Protein Deficiency and Infantile Refsum Disease.

For research use only. We do not sell to patients.

Trihydroxycholestanoic acid Chemical Structure

CAS No. : 547-98-8

Size	Price	Stock	Quantity
500 μg	USD 98	In-stock	Estimated Time of Arrival: December 31
1 mg	USD 160	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 500	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 800	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1600	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 2590	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 4150	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

Other Forms of Trihydroxycholestanoic acid:

Trihydroxycholestanoic acid-d₃ In-stock

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Biological Activity
Purity & Documentation
References
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Description

In Vitro

Endogenous metabolites is defined as those that are annotated by Kyoto Encyclopedia of Genes and Genomes as substrates or products of the ~1900 metabolic enzymes encoded in our genome. It is clear in the body of literature that there are documented toxic properties for many of these metabolites^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

450.65

Formula

C₂₇H₄₆O₅

CAS No.

547-98-8

Appearance

Solid

Color

White to off-white

SMILES

CC(C(O)=O)CCC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])[C@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])C[C@H](O)[C@]12C

Structure Classification

Steroids

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (110.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2190 mL	11.0951 mL	22.1902 mL
5 mM	0.4438 mL	2.2190 mL	4.4380 mL
10 mM	0.2219 mL	1.1095 mL	2.2190 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.75%

Select Batch:

Data Sheet (273 KB) SDS (392 KB)

COA (251 KB) HNMR (315 KB) RP-HPLC (245 KB) MS (68 KB)

Handling Instructions (2659 KB)

References

[1]. Lee N, et al. Endogenous toxic metabolites and implications in cancer therapy. Oncogene. 2020 Aug;39(35):5709-5720. [Content Brief]

[2]. Baumgartner MR, et al. Clinical approach to inherited peroxisomal disorders: a series of 27 patients. Ann Neurol. 1998 Nov;44(5):720-30. [Content Brief]

[3]. Poll-The BT, et al. Infantile Refsum's disease: biochemical findings suggesting multiple peroxisomal dysfunction. J Inherit Metab Dis. 1986;9(2):169-74. [Content Brief]

[4]. Rizzo C, et al. Characteristic acylcarnitine profiles in inherited defects of peroxisome biogenesis: a novel tool for screening diagnosis using tandem mass spectrometry. Pediatr Res. 2003 Jun;53(6):1013-8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.2190 mL	11.0951 mL	22.1902 mL	55.4754 mL
	5 mM	0.4438 mL	2.2190 mL	4.4380 mL	11.0951 mL
	10 mM	0.2219 mL	1.1095 mL	2.2190 mL	5.5475 mL
	15 mM	0.1479 mL	0.7397 mL	1.4793 mL	3.6984 mL
	20 mM	0.1110 mL	0.5548 mL	1.1095 mL	2.7738 mL
	25 mM	0.0888 mL	0.4438 mL	0.8876 mL	2.2190 mL
	30 mM	0.0740 mL	0.3698 mL	0.7397 mL	1.8492 mL
	40 mM	0.0555 mL	0.2774 mL	0.5548 mL	1.3869 mL
	50 mM	0.0444 mL	0.2219 mL	0.4438 mL	1.1095 mL
	60 mM	0.0370 mL	0.1849 mL	0.3698 mL	0.9246 mL
	80 mM	0.0277 mL	0.1387 mL	0.2774 mL	0.6934 mL
	100 mM	0.0222 mL	0.1110 mL	0.2219 mL	0.5548 mL

Trihydroxycholestanoic acid Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Trihydroxycholestanoic acid547-98-8Coprocholic acidEndogenous Metaboliteactive compoundsubstrateperoxisomalbeta-oxidation systemintermediatebiosynthesischolic acidInhibitorinhibitorinhibit

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