2. Immunology/Inflammation
  3. Interleukin Related
  4. Triptoquinone B

Triptoquinone B  (Synonyms: (+)-Triptoquinone B)

Cat. No.: HY-N1120
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Triptoquinone B ((+)-Triptoquinone B), a sesquiterpene alkaloid, is an interleukin-1 inhibitor. Triptoquinone B shows potent inhibitory activities against interleukin 1α and β releases for human peripheral mononuclear cells.

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Triptoquinone B Chemical Structure

Triptoquinone B Chemical Structure

CAS No. : 142937-50-6

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Based on 1 publication(s) in Google Scholar

Triptoquinone B Related Antibodies

Top Publications Citing Use of Products

View All Interleukin Related Isoform Specific Products:

View All Isoforms
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

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Description

Triptoquinone B ((+)-Triptoquinone B), a sesquiterpene alkaloid, is an interleukin-1 inhibitor. Triptoquinone B shows potent inhibitory activities against interleukin 1α and β releases for human peripheral mononuclear cells[1][2].

IC50 & Target[1]

IL-1

 

Cellular Effect
Cell Line Type Value Description References
A549 IC50
19.91 μM
Compound: 9
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
[PMID: 27133593]
Bcap37 IC50
13.29 μM
Compound: 9
Cytotoxicity against human Bcap37 cells after 48 hrs by MTT assay
Cytotoxicity against human Bcap37 cells after 48 hrs by MTT assay
[PMID: 27133593]
Hep 3B2 IC50
25.98 μM
Compound: 9
Cytotoxicity against human Hep3B cells after 48 hrs by MTT assay
Cytotoxicity against human Hep3B cells after 48 hrs by MTT assay
[PMID: 27133593]
HepG2 IC50
26.3 μM
Compound: 9
Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay
[PMID: 27133593]
MCF7 IC50
16.69 μM
Compound: 9
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
[PMID: 27133593]
U-251 IC50
> 100 μM
Compound: 9
Cytotoxicity against human U251 cells after 48 hrs by MTT assay
Cytotoxicity against human U251 cells after 48 hrs by MTT assay
[PMID: 27133593]
Molecular Weight

330.42

Formula

C20H26O4
CAS No.
SMILES

O=C1C(C(C)C)=CC(C([C@@]2(C)CC3)=C1CC[C@@]2([H])[C@@](C)(CO)C3=O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Triptoquinone B Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Triptoquinone B142937-50-6(+)-Triptoquinone BInterleukin RelatedILinterleukin-1Inhibitorinhibitorinhibit

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