2. Neuronal Signaling Protein Tyrosine Kinase/RTK
  3. Trk Receptor
  4. Trk-IN-8

Trk-IN-8 is a potent TRK inhibitor with IC50s of 0.42, 0.89 and 1.5 nM for TRKAa, TRKA(G595R) and TRKC(G623R), respectively (WO2021115401A1, compound 3).

For research use only. We do not sell to patients.

Trk-IN-8 Chemical Structure

Trk-IN-8 Chemical Structure

CAS No. : 2762200-57-5

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Trk-IN-8 Related Antibodies

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TrkA TrkB TrkC Trk

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Description

Trk-IN-8 is a potent TRK inhibitor with IC50s of 0.42, 0.89 and 1.5 nM for TRKAa, TRKA(G595R) and TRKC(G623R), respectively (WO2021115401A1, compound 3)[1].

IC50 & Target

TrkA

 

TrkC

 

Molecular Weight

386.36

Formula

C18H16F2N6O2
CAS No.
SMILES

O=C1N[C@H](C2)C[C@H]2OC3=NC=C(F)C=C3[C@@H](C)/N=C(N4)\C(F)=CN5C4=C1C=N5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Trk-IN-8 Related Classifications

  • Molarity Calculator

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Trk-IN-82762200-57-5Trk ReceptorTropomyosin related kinase receptorInhibitorinhibitorinhibit

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