2. Anti-infection
  3. Reverse Transcriptase
  4. Trovirdine hydrochloride

Trovirdine hydrochloride  (Synonyms: LY 300046 hydrochloride)

Cat. No.: HY-15350
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Trovirdine hydrochloride, a phenethylthiazolylthiourea (PETT) derivative, is an HIV reverse transcriptase (RT) non-nucleoside inhibitor (NNI). A novel computer model of the RT/NNI binding pocket revealed spatial gaps around Trovirdine hydrochloride's pyridyl ring. Docking studies suggested that replacing this planar ring with a nonplanar piperidinyl or piperazinyl ring could better occupy the binding pocket, enhancing anti-HIV activity. Synthesized heterocyclic compounds based on this modification demonstrated greater potency than Trovirdine hydrochloride, effectively inhibiting HIV replication at nanomolar concentrations without cytotoxicity in infected peripheral blood mononuclear cells.

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Trovirdine hydrochloride Chemical Structure

Trovirdine hydrochloride Chemical Structure

CAS No. : 148311-89-1

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Trovirdine hydrochloride Related Antibodies

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Description

Trovirdine hydrochloride, a phenethylthiazolylthiourea (PETT) derivative, is an HIV reverse transcriptase (RT) non-nucleoside inhibitor (NNI). A novel computer model of the RT/NNI binding pocket revealed spatial gaps around Trovirdine hydrochloride's pyridyl ring. Docking studies suggested that replacing this planar ring with a nonplanar piperidinyl or piperazinyl ring could better occupy the binding pocket, enhancing anti-HIV activity. Synthesized heterocyclic compounds based on this modification demonstrated greater potency than Trovirdine hydrochloride, effectively inhibiting HIV replication at nanomolar concentrations without cytotoxicity in infected peripheral blood mononuclear cells[1].

Cellular Effect
Cell Line Type Value Description References
MT4 EC50
0.02 μM
Compound: Trovirdine
Effective concentration require to protect MT-4 cells from human immunodeficiency virus type 1 induced cytopathogenicity was determined by MTT method
Effective concentration require to protect MT-4 cells from human immunodeficiency virus type 1 induced cytopathogenicity was determined by MTT method
[PMID: 15916438]
MT4 EC50
1.2 μM
Compound: Trovirdine
Effective concentration require to protect MT-4 cells from HIV-1 Y181C mutant induced cytopathogenicity was determined by MTT method
Effective concentration require to protect MT-4 cells from HIV-1 Y181C mutant induced cytopathogenicity was determined by MTT method
[PMID: 15916438]
MT4 CC50
60 μM
Compound: Trovirdine
Cytotoxic concentration required to reduce the viability of mock infected MT-4 cells determined by MTT method
Cytotoxic concentration required to reduce the viability of mock infected MT-4 cells determined by MTT method
[PMID: 15916438]
Molecular Weight

373.70

Formula

C13H14BrClN4S
CAS No.
SMILES

S=C(NCCC1=NC=CC=C1)NC2=NC=C(Br)C=C2.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Trovirdine hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Trovirdine148311-89-1LY 300046LY300046LY-300046Reverse TranscriptaseInhibitorinhibitorinhibit

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