2. Apoptosis Protein Tyrosine Kinase/RTK JAK/STAT Signaling Metabolic Enzyme/Protease
  3. Ferroptosis EGFR TrxR Apoptosis
  4. TrxR/EGFR-IN-1

TrxR/EGFR-IN-1 (Compound L1Au2) is a TrxR/EGFR inhibitor. TrxR/EGFR-IN-1 is active against both Gefitinib (HY-50895)-sensitive and resistant lung cancers, effectively inhibiting tumor proliferation and promoting apoptosis. TrxR/EGFR-IN-1 promotes the degradation of GPX4 protein through autophagolysosomal and proteasomal pathways, leading to ferroptosis. In addition, TrxR/EGFR-IN-1 can induce endoplasmic reticulum stress and trigger immunogenic cell death. TrxR/EGFR-IN-1 can be used for the research of Gefitinib (HY-50895)-resistant lung cancer.

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TrxR/EGFR-IN-1 Chemical Structure

TrxR/EGFR-IN-1 Chemical Structure

CAS No. : 3038386-42-1

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TrxR/EGFR-IN-1 Related Antibodies

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TrxR1

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Description

TrxR/EGFR-IN-1 (Compound L1Au2) is a TrxR/EGFR inhibitor. TrxR/EGFR-IN-1 is active against both Gefitinib (HY-50895)-sensitive and resistant lung cancers, effectively inhibiting tumor proliferation and promoting apoptosis. TrxR/EGFR-IN-1 promotes the degradation of GPX4 protein through autophagolysosomal and proteasomal pathways, leading to ferroptosis. In addition, TrxR/EGFR-IN-1 can induce endoplasmic reticulum stress and trigger immunogenic cell death. TrxR/EGFR-IN-1 can be used for the research of Gefitinib (HY-50895)-resistant lung cancer[1].

Molecular Weight

710.88

Formula

C24H24AuClFN6O2P
CAS No.
SMILES

ClC1=C(F)C=CC(NC2=NC=NC3=C2C=C(OCC#C[Au][P]45CN6CN(CN(C6)C5)C4)C(OC)=C3)=C1
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
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TrxR/EGFR-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TrxR/EGFR-IN-13038386-42-1FerroptosisEGFRTrxRApoptosisEpidermal growth factor receptorErbB-1HER1Thioredoxin ReductasePC9 cellsPC9GR cellsH1975 cellsBeas-2b cellsLung cancer modelInhibitorinhibitorinhibit

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