2. Cell Cycle/DNA Damage Cytoskeleton Apoptosis
  3. Microtubule/Tubulin Apoptosis
  4. Tubulin inhibitor 47

Tubulin inhibitor 47 (compound C11) is a potent tubulin inhibitor. Tubulin inhibitor 47 induces apoptosis and cell cycle arrest at the M phase. Tubulin inhibitor 47 shows anti-tumor activity.

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Tubulin inhibitor 47 Chemical Structure

Tubulin inhibitor 47 Chemical Structure

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Tubulin inhibitor 47 Related Antibodies

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Description

Tubulin inhibitor 47 (compound C11) is a potent tubulin inhibitor. Tubulin inhibitor 47 induces apoptosis and cell cycle arrest at the M phase. Tubulin inhibitor 47 shows anti-tumor activity[1].

In Vitro

Tubulin inhibitor 47 (compound C11) targets the colchicine site of tubulin to inhibit its polymerization[1].
Tubulin inhibitor 47 (0, 2, 4, 6, 8, 10 nM) induces cell cycle arrest at the M phase[1].
Tubulin inhibitor 47 (0, 5, 10, 20 nM) increases the expression of p-Histone H3 in KYSE30 cells in a dose-dependent manner[1].
Tubulin inhibitor 47 (0, 5, 10, 20 nM; 48 h) induces apoptosis in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tubulin inhibitor 47 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: MGC-803, KYSE-30, HCT-116 cells
Concentration: 0-10 µM
Incubation Time: 48 h
Result: Showed antiproliferative activities with IC50s of 0.014, 0.013, 0.026 µM for MGC-803, KYSE-30, HCT-116 cells, respectively.

Apoptosis Analysis[1]

Cell Line: KYSE30, KYSE70 cells
Concentration: 5, 10, 20 nM
Incubation Time: 48 h
Result: Induced apoptosis and decreased the expression of cleaved-PARP, cleaved-caspase 9/7/3 protein.

Cell Cycle Analysis[1]

Cell Line: KYSE30, KYSE70 cells
Concentration: 5, 10, 20 nM
Incubation Time:
Result: Induced cell cycle arrest at M phase in a dose-dependent manner.
In Vivo

Tubulin inhibitor 47 (6, 12 mg/kg; i.p.; daily for 15 days) shows anti-tumor activity in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-8 weeks, female BALA/c-nu nude mice (KYSE30 cells)[1]
Dosage: 6, 12 mg/kg
Administration: I.p.; daily for 15 days
Result: Decreased tumor growth in a dose-dependent manner and showed no significant changes in animal weight during treatment.
Molecular Weight

316.35

Formula

C20H16N2O2
SMILES

CC(C=C1C2=C(C3=CC=C(OC)C=C3)C=NO2)=NC4=C1C=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Tubulin inhibitor 47 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tubulin inhibitor 47Tubulin inhibitor47Tubulin inhibitor-47Microtubule/TubulinApoptosisapoptosisM phaseKYSE30 cellsanti-tumortubulin polymerizationInhibitorinhibitorinhibit

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