2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. Tubulin polymerization-IN-18

Tubulin polymerization-IN-18 (compound 8) is a potent inhibitor of tubulin polymerization. Tubulin polymerization-IN-18 has the potential for the research of breast cancers and chemoresistant colon cancers.

For research use only. We do not sell to patients.

Tubulin polymerization-IN-18 Chemical Structure

Tubulin polymerization-IN-18 Chemical Structure

CAS No. : 1258011-23-2

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Tubulin polymerization-IN-18 Related Antibodies

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Description

Tubulin polymerization-IN-18 (compound 8) is a potent inhibitor of tubulin polymerization. Tubulin polymerization-IN-18 has the potential for the research of breast cancers and chemoresistant colon cancers[1].

Cellular Effect
Cell Line Type Value Description References
Epithelial cell IC50
10 mM
Compound: 35
Cytotoxicity against in CD1 mouse mammary epithelial cells after 72 hrs by alamar blue dye assay
Cytotoxicity against in CD1 mouse mammary epithelial cells after 72 hrs by alamar blue dye assay
[PMID: 21080725]
MCF7 IC50
0.0096 μM
Compound: 35
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
[PMID: 21080725]
MDA-MB-231 IC50
0.0288 μM
Compound: 35
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
[PMID: 21080725]
Molecular Weight

435.47

Formula

C25H25NO6
CAS No.
SMILES

COC1=CC(N2C([C@H]([C@@H]2C3=CC(O)=C(C=C3)OC)C4=CC=CC=C4)=O)=CC(OC)=C1OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Tubulin polymerization-IN-18 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tubulin polymerization-IN-181258011-23-2Microtubule/Tubulintubulin polymerizationbreastchemoresistant colonInhibitorinhibitorinhibit

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