2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. Tubulin polymerization-IN-37

Tubulin polymerization-IN-37 is a tubulin polymerization inhibitor (IC50: 2.3 μΜ). Tubulin polymerization-IN-37 binds to the colchicine site of tubulin and inhibits colchicine binding. Tubulin polymerization-IN-37 can be used in the research of cancers, such as lymphomas.

For research use only. We do not sell to patients.

Tubulin polymerization-IN-37 Chemical Structure

Tubulin polymerization-IN-37 Chemical Structure

CAS No. : 2011784-92-0

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Tubulin polymerization-IN-37 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Tubulin polymerization-IN-37 is a tubulin polymerization inhibitor (IC50: 2.3 μΜ). Tubulin polymerization-IN-37 binds to the colchicine site of tubulin and inhibits colchicine binding. Tubulin polymerization-IN-37 can be used in the research of cancers, such as lymphomas[1].

IC50 & Target

Tubulin polymerization[1]
Cellular Effect
Cell Line Type Value Description References
DU-145 IC50
0.99 μM
Compound: 6k
Cytotoxicity against human DU145 cells assessed as growth inhibition after 72 hrs by MTS assay
Cytotoxicity against human DU145 cells assessed as growth inhibition after 72 hrs by MTS assay
[PMID: 27643641]
M14 IC50
0.89 μM
Compound: 6k
Cytotoxicity against human M14 cells assessed as growth inhibition after 72 hrs by MTS assay
Cytotoxicity against human M14 cells assessed as growth inhibition after 72 hrs by MTS assay
[PMID: 27643641]
MCF-10A IC50
> 100 μM
Compound: 6k
Cytotoxicity against human MCF10A cells assessed as growth inhibition after 72 hrs by MTS assay
Cytotoxicity against human MCF10A cells assessed as growth inhibition after 72 hrs by MTS assay
[PMID: 27643641]
MCF7 IC50
0.92 μM
Compound: 6k
Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTS assay
Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTS assay
[PMID: 27643641]
MDA-MB-231 IC50
0.75 μM
Compound: 6k
Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by MTS assay
Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by MTS assay
[PMID: 27643641]
PC-3 IC50
0.87 μM
Compound: 6k
Cytotoxicity against human PC3 cells assessed as growth inhibition after 72 hrs by MTS assay
Cytotoxicity against human PC3 cells assessed as growth inhibition after 72 hrs by MTS assay
[PMID: 27643641]
WI-38 IC50
> 100 μM
Compound: 6k
Cytotoxicity against human WI38 cells assessed as growth inhibition after 72 hrs by MTS assay
Cytotoxicity against human WI38 cells assessed as growth inhibition after 72 hrs by MTS assay
[PMID: 27643641]
In Vitro

Tubulin polymerization-IN-37 (compound 2f, 1 μΜ, 72 h) inhibits proliferation of lymphoma cells below 50%[1].
Tubulin polymerization-IN-37 (50 and 500 nM, 24-72 h) induces cell apoptosis and arrests cell in G2/M phase in VL51 and MINO cells[1].
Tubulin polymerization-IN-37 (5 μΜ) inhibits colchicine binding to tubulin by 80%[1].
Tubulin polymerization-IN-37 shows cytotoxicity against MCF-7 cells (IC50: 0.21 μΜ)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tubulin polymerization-IN-37 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: VL51, MINO, HBL1, SU-DHL-10 cells.
Concentration: 0-10 μΜ
Incubation Time: 72 h
Result: Inhibited cell proliferation to 28.1%, 8.6%, 7.3%, 13.8% at 1 μΜ, respectively. IC50s: 0.12, 0.07, 0.08, 0.07 μΜ, respectively.

Cell Cycle Analysis[1]

Cell Line: VL51 and MINO cells
Concentration: 50 and 500 nM
Incubation Time: 24, 48 and 72 h
Result: Arrested cell in G2/M phase.
Molecular Weight

340.37

Formula

C19H20N2O4
CAS No.
SMILES

COC1=CC(CN2C=C3CCC4=C(C3=C2)ON=C4)=CC(OC)=C1OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Tubulin polymerization-IN-37 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tubulin polymerization-IN-372011784-92-0Microtubule/TubulinAntitubulinlymphomacancerVL51MINOMCF-7colchicineInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Tubulin polymerization-IN-37
Cat. No.:
HY-151398
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (0 KB) Français - FR (0 KB) Deutsch - DE (0 KB) Norwegian - NO (0 KB) Español - ES (0 KB) Swedish - SV (0 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.