2. Neuronal Signaling Protein Tyrosine Kinase/RTK
  3. Trk Receptor
  4. Type II TRK inhibitor 2

Type II TRK inhibitor 2 (compound 40l) is a selective type II TRK inhibitor with plasma stability and moderate hepatic microsomal stability. Type II TRK inhibitor 2 significantly inhibits Km-12, Ba/F3-TRKAG595R and Ba/F3-TRKAG667C cell proliferation (IC50: 4.1 nM, 41.5 nM, 1.4 nM). Type II TRK inhibitor 2 can be used to study NTRK fusion cancers.

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Type II TRK inhibitor 2 Chemical Structure

Type II TRK inhibitor 2 Chemical Structure

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Type II TRK inhibitor 2 Related Antibodies

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Description

Type II TRK inhibitor 2 (compound 40l) is a selective type II TRK inhibitor with plasma stability and moderate hepatic microsomal stability. Type II TRK inhibitor 2 significantly inhibits Km-12, Ba/F3-TRKAG595R and Ba/F3-TRKAG667C cell proliferation (IC50: 4.1 nM, 41.5 nM, 1.4 nM). Type II TRK inhibitor 2 can be used to study NTRK fusion cancers[1].

Molecular Weight

567.59

Formula

C30H27F2N9O
SMILES

O=C(NC1=CC(C(C)(C)C)=NN1C2=CC(F)=CC(F)=C2)NC3=CC=CC(NC4=CC5=C(C=C4)C(C6=CNN=C6)=NN5)=C3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Type II TRK inhibitor 2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Type II TRK inhibitor 2Trk ReceptorTropomyosin related kinase receptorPlasma stabilitymoderate liver microsomal stabilityNTRK fusion cancerInhibitorinhibitorinhibit

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