1. GPCR/G Protein MAPK/ERK Pathway Stem Cell/Wnt
  2. Ras ERK
  3. UC-857993

UC-857993 is a selective SOS1-Ras inhibitor (Kd=14.7 μM, His6-SOS1cat), suppressing catalytic activity. UC-857993 also inhibits ERK and Ras activation, suppresses the growth of mouse embryonic fibroblasts (MEFs).

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UC-857993 Chemical Structure

UC-857993 Chemical Structure

CAS No. : 487001-04-7

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Description

UC-857993 is a selective SOS1-Ras inhibitor (Kd=14.7 μM, His6-SOS1cat), suppressing catalytic activity. UC-857993 also inhibits ERK and Ras activation, suppresses the growth of mouse embryonic fibroblasts (MEFs)[1].

In Vitro

UC-857993 (0-80 μM; 3 d) specifically inhibits the growth of wild-type MEFs, but did not inhibit the growth of carcinogenic H-Ras(G12V) expressing MEF[1].
UC-857993 (60 μM, 80 μM; 2 h) dose-dependently inhibits Ras activation and downstream ERK activation mediated through EGFR-SOS1-Ras-Raf1-MEK-ERK signaling[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: Mouse embryonic fibroblasts
Concentration: 0, 40, 60, and 80 μ M
Incubation Time: 3 days
Result: Selectively inhibited the growth of mouse fibroblasts, as exerting inhibition against wild-type mouse embryonic fibroblasts but not mouse embryonic fibroblasts expressing carcinogenic H-Ras(G12V).

Western Blot Analysis[1]

Cell Line: NIH/3T3 cells
Concentration: 60 μM, 80 μM
Incubation Time: 2 hours; stimulated with 50 ng/ml EGF for 5 min
Result: Inhibited EGF-induced the increase of the level of p-ERK and Ras-GTP.
Molecular Weight

403.90

Formula

C25H22ClNO2

CAS No.
SMILES

O=C(C1=CC2=C3N(C(C4=CC=CC=C4Cl)C5C2C=CC5)CC(CC=C6)C6C3=C1)O

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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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UC-857993
Cat. No.:
HY-124514
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