2. Neuronal Signaling Metabolic Enzyme/Protease
  3. OGT Endogenous Metabolite
  4. UDP-glucosamine disodium

UDP-glucosamine (UDP-GlcNAc) disodium is a substrate for O-GlcNAc transferase, which catalyzes the attachment of O-GlcNAc to proteins. O-GlcNAcase catalyzes the removal of O-GlcNAc from proteins. UDP-glucosamine (UDP-GlcNAc) disodium is the end product of the hexosamine biosynthesis pathway, which is regulated primarily by glucose-6-phosphate-Glutamine:fructose-6-phosphate amidotransferase (GFAT).

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UDP-glucosamine disodium Chemical Structure

UDP-glucosamine disodium Chemical Structure

CAS No. : 1355005-51-4

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UDP-glucosamine disodium Related Antibodies

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Description

UDP-glucosamine (UDP-GlcNAc) disodium is a substrate for O-GlcNAc transferase, which catalyzes the attachment of O-GlcNAc to proteins. O-GlcNAcase catalyzes the removal of O-GlcNAc from proteins. UDP-glucosamine (UDP-GlcNAc) disodium is the end product of the hexosamine biosynthesis pathway, which is regulated primarily by glucose-6-phosphate-Glutamine:fructose-6-phosphate amidotransferase (GFAT)[1].

Molecular Weight

609.28

Formula

C15H23N3Na2O16P2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@@](N2C(NC(C=C2)=O)=O)([H])O[C@@H]([C@H]1O)COP(OP(O[C@H]3O[C@@H]([C@H]([C@@H]([C@H]3N)O)O)CO)(O[Na])=O)(O[Na])=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 250 mg/mL (410.32 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6413 mL 8.2064 mL 16.4128 mL
5 mM 0.3283 mL 1.6413 mL 3.2826 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.6413 mL 8.2064 mL 16.4128 mL 41.0320 mL
5 mM 0.3283 mL 1.6413 mL 3.2826 mL 8.2064 mL
10 mM 0.1641 mL 0.8206 mL 1.6413 mL 4.1032 mL
15 mM 0.1094 mL 0.5471 mL 1.0942 mL 2.7355 mL
20 mM 0.0821 mL 0.4103 mL 0.8206 mL 2.0516 mL
25 mM 0.0657 mL 0.3283 mL 0.6565 mL 1.6413 mL
30 mM 0.0547 mL 0.2735 mL 0.5471 mL 1.3677 mL
40 mM 0.0410 mL 0.2052 mL 0.4103 mL 1.0258 mL
50 mM 0.0328 mL 0.1641 mL 0.3283 mL 0.8206 mL
60 mM 0.0274 mL 0.1368 mL 0.2735 mL 0.6839 mL
80 mM 0.0205 mL 0.1026 mL 0.2052 mL 0.5129 mL
100 mM 0.0164 mL 0.0821 mL 0.1641 mL 0.4103 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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UDP-glucosamine disodium Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UDP-glucosamine disodium1355005-51-4OGTEndogenous MetaboliteO-linked N-acetylglucosaminyltransferaseO-GlcNAc transferasesubstratehexosamine biosynthesis pathwayGFATInhibitorinhibitorinhibit

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