2. Anti-infection
  3. Bacterial
  4. UX4O

UX4O is an allosteric inhibitor of UDP-glucose dehydrogenase UGDH. hUGDH is a hexamer that can catalyze the oxidation of UDP-glucose to UDP-glucuronic acid. hUGDH has an active (E) state and an inactive (EΩ) state, and it needs to bind to the allosteric inhibitor UDP-xylose (UDP-Xyl) to be stabilized in the inactive state. And UX4O may also be a physiologically relevant inhibitor of allosteric UGDH in bacteria that do not produce UDP-Xyl.

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UX4O Chemical Structure

UX4O Chemical Structure

CAS No. : 25747-29-9

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UX4O Related Antibodies

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Description

UX4O is an allosteric inhibitor of UDP-glucose dehydrogenase UGDH. hUGDH is a hexamer that can catalyze the oxidation of UDP-glucose to UDP-glucuronic acid. hUGDH has an active (E) state and an inactive (EΩ) state, and it needs to bind to the allosteric inhibitor UDP-xylose (UDP-Xyl) to be stabilized in the inactive state. And UX4O may also be a physiologically relevant inhibitor of allosteric UGDH in bacteria that do not produce UDP-Xyl[1].

IC50 & Target

UGDH[1]
Molecular Weight

534.26

Formula

C14H20N2O16P2
CAS No.
SMILES

O=C(C=CN1[C@H]2[C@H](O)[C@H](O)[C@@H](COP(OP(O[C@@H](OC3)[C@H](O)[C@@H](O)C3=O)(O)=O)(O)=O)O2)NC1=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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UX4O Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UX4O25747-29-9UDP-4-keto-xyloseBacterialInhibitorinhibitorinhibit

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