Valbenazine tosylate (Synonyms: NBI-98854 tosylate)

Cat. No.: HY-16771A: FAQs
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Valbenazine tosylate (NBI-98854 tosylate) is a vesicular monoamine transporter 2 (VMAT2) inhibitor with the K_i of 110-190 nM.

For research use only. We do not sell to patients.

Valbenazine tosylate Chemical Structure

CAS No. : 1639208-54-0

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Other In-stock Forms of Valbenazine tosylate:

Valbenazine

Other Forms of Valbenazine tosylate:

Valbenazine In-stock

3 Publications Citing Use of MCE Valbenazine tosylate

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Description

Valbenazine tosylate (NBI-98854 tosylate) is a vesicular monoamine transporter 2 (VMAT2) inhibitor with the K_i of 110-190 nM^[1].

In Vitro

Valbenazine exhibits VMAT2 binding affinity in rat striatum and human platelets with K_is of 110 and 150 nM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Valbenazine (10 mg/kg; orally) induces ptosis (primarily an adrenergic response) and increases plasma prolactin primarily a dopaminergic response in rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

762.97

Formula

C₃₈H₅₄N₂O₁₀S₂

CAS No.

1639208-54-0

SMILES

O=C([C@@H](N)C(C)C)O[C@@H]1C[C@]2([H])C3=CC(OC)=C(OC)C=C3CCN2C[C@H]1CC(C)C.O=S(C4=CC=C(C)C=C4)(O)=O.O=S(C5=CC=C(C)C=C5)(O)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Dimitri E Grigoriadis, et al. Pharmacologic Characterization of Valbenazine (NBI-98854) and Its Metabolites. J Pharmacol Exp Ther. 2017 Jun;361(3):454-461. [Content Brief]

Valbenazine tosylate Related Classifications

Neurological Disease

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Valbenazine1639208-54-0NBI-98854NBI98854NBI 98854Monoamine TransporterHuntingtondiseasevesicularmonoaminetransporterVMAT2Inhibitorinhibitorinhibit

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