Valerena-4,7(11)-diene

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Valerena-4,7(11)-diene is a tranquilizer. Valerena-4,7(11)-diene suppresses stress-induced excitatory behaviors. Valerena-4,7(11)-diene is expressed via olfactory stimulation and pulmonary absorption.

For research use only. We do not sell to patients.

Valerena-4,7(11)-diene Chemical Structure

CAS No. : 351222-66-7

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Description

In Vivo

Valerena-4,7(11)-diene (30, 300 µg/cage; inhalation administration) suppresses stress-induced excitatory behaviors and significantly reduces stress-induced blood corticosterone, cerebral cerebral serotonin (5-HT) and dopamine (DA) levels^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Four-week-old male ddY mice^[1]
Dosage:	30, 300 µg/cage
Administration:	Inhalation administration
Result:	Significantly suppressed stress-induced behavioral changes, reduced the blood corticosterone level to 1.41 ng/mL, significantly attenuated increases in cerebral cerebral serotonin (5-HT) and dopamine (DA) levels and also decreased DA turnover in the hypothalamus and striatum after restraint stress.

Molecular Weight

204.35

Formula

C₁₅H₂₄

CAS No.

351222-66-7

SMILES

C/C(C)=C\[C@H]1C2=C(C)CC[C@]2([H])[C@@H](CC1)C

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Takemoto H, et al. Inhalation administration of valerena-4,7(11)-diene from Nardostachys chinensis roots ameliorates restraint stress-induced changes in murine behavior and stress-related factors. Biol Pharm Bull. 2014;37(6):1050-5. [Content Brief]