2. Protein Tyrosine Kinase/RTK Stem Cell/Wnt JAK/STAT Signaling
  3. VEGFR STAT
  4. VEGFR-2/STAT-3-IN-1

VEGFR-2/STAT-3-IN-1 (Compound 9f) is a dual inhibitor for VEGFR-2 (IC50=26.3 nM) and STAT-3 (IC50=5.63 nM). VEGFR-2/STAT-3-IN-1 inhibits the proliferation of cancer cells PANC1 and PC3 with IC50 of 0.14 and 0.10 µM. VEGFR-2/STAT-3-IN-1 induces apoptosis in PC3.

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VEGFR-2/STAT-3-IN-1 Chemical Structure

VEGFR-2/STAT-3-IN-1 Chemical Structure

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VEGFR-2/STAT-3-IN-1 Related Antibodies

Top Publications Citing Use of Products

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

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STAT3 STAT5 STAT6 STAT1

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Description

VEGFR-2/STAT-3-IN-1 (Compound 9f) is a dual inhibitor for VEGFR-2 (IC50=26.3 nM) and STAT-3 (IC50=5.63 nM). VEGFR-2/STAT-3-IN-1 inhibits the proliferation of cancer cells PANC1 and PC3 with IC50 of 0.14 and 0.10 µM. VEGFR-2/STAT-3-IN-1 induces apoptosis in PC3[1].

IC50 & Target

VEGFR2

26.3 nM (IC50)

STAT3

5.63 nM (IC50)

Molecular Weight

480.47

Formula

C26H20N6O4
SMILES

O=C(N1C(C2=CC=CC=C2)=O)/C(C3=C1C=CC=C3)=N\NC(C4=C(C)N(C5=CC=C(OC)C=C5)N=N4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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VEGFR-2/STAT-3-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VEGFR-2/STAT-3-IN-1VEGFRSTATVascular endothelial growth factor receptorPANC-1PC3pancreatic cancerprostate cancerInhibitorinhibitorinhibit

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