2. Metabolic Enzyme/Protease
  3. LDLR
  4. VH4127

VH4127 is a cyclic peptide targeting the low density lipoprotein receptor (LDLR) with a KD of 18 nM for hLDLR. VH4127, bearing non-natural amino acid residues, specifically binds to rodent and human epidermal growth factor (EGF) homology domain of LDLR.

For research use only. We do not sell to patients.

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VH4127 Chemical Structure

VH4127 Chemical Structure

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VH4127 Related Antibodies

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Description

VH4127 is a cyclic peptide targeting the low density lipoprotein receptor (LDLR) with a KD of 18 nM for hLDLR. VH4127, bearing non-natural amino acid residues, specifically binds to rodent and human epidermal growth factor (EGF) homology domain of LDLR[1][2].

IC50 & Target[1]

hLDLR

18 nM (Kd)

Molecular Weight

1048.37

Formula

C41H73N15O9S4
Sequence

cyclo[{d-Cys}-Met-{Thz}-Arg-Leu-Arg-Gly-{Pen}]
Sequence Shortening

cyclo[{d-Cys}-M-{Thz}-RLRG-{Pen}]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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VH4127 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VH4127VH 4127VH-4127LDLRLow-density lipoprotein receptorcyclic peptidelow density lipoproteinnon-natural amino acidInhibitorinhibitorinhibit

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HY-P10697
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